Concomitant vascular reconstruction during pancreatectomy for malignant disease: a propensity score-adjusted, population-based trend analysis involving 10,206 patients.


Journal Article

OBJECTIVE: To assess trends in the frequency of concomitant vascular reconstructions (VRs) from 2000 through 2009 among patients who underwent pancreatectomy, as well as to compare the short-term outcomes between patients who underwent pancreatic resection with and without VR. DESIGN: Single-center series have been conducted to evaluate the short-term and long-term outcomes of VR during pancreatic resection. However, its effectiveness from a population-based perspective is still unknown. Unadjusted, multivariable, and propensity score-adjusted generalized linear models were performed. SETTING: Nationwide Inpatient Sample from 2000 through 2009. PATIENTS: A total of 10,206 patients were involved. MAIN OUTCOME MEASURES: Incidence of VR during pancreatic resection, perioperative in-hospital complications, and length of hospital stay. RESULTS: Overall, 10,206 patients were included in this analysis. Of these, 412 patients (4.0%) underwent VR, with the rate increasing from 0.7% in 2000 to 6.0% in 2009 (P < .001). Patients who underwent pancreatic resection with VR were at a higher risk for intraoperative (propensity score-adjusted odds ratio, 1.94; P = .001) and postoperative (propensity score-adjusted odds ratio, 1.36; P = .008) complications, while the mortality and median length of hospital stay were similar to those of patients without VR. Among the 25% of hospitals with the highest surgical volume, patients who underwent pancreatic surgery with VR had significantly higher rates of postoperative complications and mortality than patients without VR. CONCLUSIONS: The frequency of VR during pancreatic surgery is increasing in the United States. In contrast with most single-center analyses, this population-based study demonstrated that patients who underwent VR during pancreatic surgery had higher rates of adverse postoperative outcomes than their counterparts who underwent pancreatic resection only. Prospective studies incorporating long-term outcomes are warranted to further define which patients benefit from VR.

Full Text

Cited Authors

  • Worni, M; Castleberry, AW; Clary, BM; Gloor, B; Carvalho, E; Jacobs, DO; Pietrobon, R; Scarborough, JE; White, RR

Published Date

  • April 2013

Published In

Volume / Issue

  • 148 / 4

Start / End Page

  • 331 - 338

PubMed ID

  • 23715922

Pubmed Central ID

  • 23715922

Electronic International Standard Serial Number (EISSN)

  • 2168-6262

International Standard Serial Number (ISSN)

  • 2168-6254

Digital Object Identifier (DOI)

  • 10.1001/jamasurg.2013.1058


  • eng