Recurrence after operative management of intrahepatic cholangiocarcinoma.


Journal Article

INTRODUCTION: Data on recurrence after operation for intrahepatic cholangiocarcinoma (ICC) are limited. We sought to investigate rates and patterns of recurrence in patients after operative intervention for ICC. METHODS: We identified 301 patients who underwent operation for ICC between 1990 and 2011 from an international, multi-institutional database. Clinicopathologic data, recurrence patterns, and recurrence-free survival (RFS) were analyzed. RESULTS: During the median follow up duration of 31 months (range 1-208), 53.5% developed a recurrence. Median RFS was 20.2 months and 5-year actuarial disease-free survival, 32.1%. The most common site for initial recurrence after operation of ICC was intrahepatic (n = 98; 60.9%), followed by simultaneous intra- and extrahepatic disease (n = 30; 18.6%); 33 (21.0%) patients developed extrahepatic recurrence only as the first site of recurrence. Macrovascular invasion (hazard ratio [HR], 2.08; 95% confidence interval [CI], 1.34-3.21; P < .001), nodal metastasis (HR, 1.55; 95% CI, 1.01-2.45; P = .04), unknown nodal status (HR, 1.57; 95% CI, 1.10-2.25; P = .04), and tumor size ≥ 5 cm (HR, 1.84; 95% CI, 1.28-2.65; P < .001) were independently associated with increased risk of recurrence. Patients were assigned a clinical score from 0 to 3 according to the presence of these risk factors. The 5-year RFS for patients with scores of 0, 1, 2, and 3 was 61.8%, 36.2%, 19.5%, and 9.6%, respectively. CONCLUSION: Recurrence after operative intervention for ICC was common. Disease recurred both at intra- and extrahepatic sites with roughly the same frequency. Factors such as lymph node metastasis, tumor size, and vascular invasion predict highest risk of recurrence.

Full Text

Cited Authors

  • Hyder, O; Hatzaras, I; Sotiropoulos, GC; Paul, A; Alexandrescu, S; Marques, H; Pulitano, C; Barroso, E; Clary, BM; Aldrighetti, L; Ferrone, CR; Zhu, AX; Bauer, TW; Walters, DM; Groeschl, R; Gamblin, TC; Marsh, JW; Nguyen, KT; Turley, R; Popescu, I; Hubert, C; Meyer, S; Choti, MA; Gigot, J-F; Mentha, G; Pawlik, TM

Published Date

  • June 2013

Published In

Volume / Issue

  • 153 / 6

Start / End Page

  • 811 - 818

PubMed ID

  • 23499016

Pubmed Central ID

  • 23499016

Electronic International Standard Serial Number (EISSN)

  • 1532-7361

Digital Object Identifier (DOI)

  • 10.1016/j.surg.2012.12.005


  • eng

Conference Location

  • United States