Zebrafish model systems for developmental neurobehavioral toxicology.
Published
Journal Article (Review)
Zebrafish offer many advantages that complement classic mammalian models for the study of normal development as well as for the teratogenic effects of exposure to hazardous compounds. The clear chorion and embryo of the zebrafish allow for continuous visualization of the anatomical changes associated with development, which, along with short maturation times and the capability of complex behavior, makes this model particularly useful for measuring changes to the developing nervous system. Moreover, the rich array of developmental, behavioral, and molecular benefits offered by the zebrafish have contributed to an increasing demand for the use of zebrafish in behavioral teratology. Essential for this endeavor has been the development of a battery of tests to evaluate a spectrum of behavior in zebrafish. Measures of sensorimotor plasticity, emotional function, cognition and social interaction have been used to characterize the persisting adverse effects of developmental exposure to a variety of chemicals including therapeutic drugs, drugs of abuse and environmental toxicants. In this review, we present and discuss such tests and data from a range of developmental neurobehavioral toxicology studies using zebrafish as a model. Zebrafish provide a key intermediate model between high throughput in vitro screens and the classic mammalian models as they have the accessibility of in vitro models and the complex functional capabilities of mammalian models.
Full Text
Duke Authors
Cited Authors
- Bailey, J; Oliveri, A; Levin, ED
Published Date
- March 2013
Published In
Volume / Issue
- 99 / 1
Start / End Page
- 14 - 23
PubMed ID
- 23723169
Pubmed Central ID
- 23723169
Electronic International Standard Serial Number (EISSN)
- 1542-9768
Digital Object Identifier (DOI)
- 10.1002/bdrc.21027
Language
- eng
Conference Location
- United States