Pump-probe nonlinear phase dispersion spectroscopy.

Published

Journal Article

Pump-probe microscopy is an imaging technique that delivers molecular contrast of pigmented samples. Here, we introduce pump-probe nonlinear phase dispersion spectroscopy (PP-NLDS), a method that leverages pump-probe microscopy and spectral-domain interferometry to ascertain information from dispersive and resonant nonlinear effects. PP-NLDS extends the information content to four dimensions (phase, amplitude, wavelength, and pump-probe time-delay) that yield unique insight into a wider range of nonlinear interactions compared to conventional methods. This results in the ability to provide highly specific molecular contrast of pigmented and non-pigmented samples. A theoretical framework is described, and experimental results and simulations illustrate the potential of this method. Implications for biomedical imaging are discussed.

Full Text

Duke Authors

Cited Authors

  • Robles, FE; Samineni, P; Wilson, JW; Warren, WS

Published Date

  • April 2013

Published In

Volume / Issue

  • 21 / 8

Start / End Page

  • 9353 - 9364

PubMed ID

  • 23609646

Pubmed Central ID

  • 23609646

Electronic International Standard Serial Number (EISSN)

  • 1094-4087

International Standard Serial Number (ISSN)

  • 1094-4087

Digital Object Identifier (DOI)

  • 10.1364/OE.21.009353

Language

  • eng