Feasibility and preliminary efficacy data from a computerized cognitive intervention in children with chromosome 22q11.2 deletion syndrome.

Journal Article (Journal Article)

Children with chromosome 22q11.2 deletion syndrome (22q11DS) are significantly impaired in their academic performance and functionality due to cognitive deficits, especially in attention, memory, and other facets of executive function. Compounding these cognitive deficits is the remarkably high risk of major psychoses, occurring in 25% of adolescents and adults with the disorder. There are currently no evidence-based interventions designed to improve the cognitive deficits in these individuals. We implemented a neuroplasticity-based computerized cognitive remediation program for 12 weeks in 13 adolescents with 22q11DS, assessed feasibility, and measured changes in cognition before and after the intervention compared to a control group of 10 age- and gender-matched children with 22q11DS. Our results indicated that despite their cognitive impairments, this intervention is feasible in children with 22q11DS, with high rates of adherence and satisfaction. Our preliminary analyses indicate that gains in cognition occur with the intervention. Further study in a larger randomized controlled trial would enable assessment of efficacy of this novel intervention.

Full Text

Duke Authors

Cited Authors

  • Harrell, W; Eack, S; Hooper, SR; Keshavan, MS; Bonner, MS; Schoch, K; Shashi, V

Published Date

  • September 2013

Published In

Volume / Issue

  • 34 / 9

Start / End Page

  • 2606 - 2613

PubMed ID

  • 23751300

Pubmed Central ID

  • PMC3724343

Electronic International Standard Serial Number (EISSN)

  • 1873-3379

Digital Object Identifier (DOI)

  • 10.1016/j.ridd.2013.05.009


  • eng

Conference Location

  • United States