Underlying potential: cellular and molecular determinants of adult liver repair.


Journal Article (Review)

The liver has a unique and extraordinary capacity for regeneration, even in adult organisms. This regenerative potential has traditionally been attributed to the replicative capabilities of mature hepatocytes and cholangiocytes, though emerging evidence suggests that other resident liver cell types such as progenitors, liver sinusoidal endothelial cells, and hepatic stellate cells respond to liver injury and contribute to repair. These other cells types are also associated with liver scarring, dysfunction, and carcinogenesis, which suggests that appropriate regulation of these cells is a major determinant of response to liver injury. The Reviews in this series explore possible contributions of liver progenitor cells, liver sinusoidal endothelial cells, and hepatic stellate cells to liver homeostasis and repair and highlight how these processes can go awry in chronic liver injury, fibrosis, and liver cancer.

Full Text

Duke Authors

Cited Authors

  • Diehl, AM; Chute, J

Published Date

  • May 2013

Published In

Volume / Issue

  • 123 / 5

Start / End Page

  • 1858 - 1860

PubMed ID

  • 23635782

Pubmed Central ID

  • 23635782

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI69966


  • eng

Conference Location

  • United States