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Underlying potential: cellular and molecular determinants of adult liver repair.

Publication ,  Journal Article
Diehl, AM; Chute, J
Published in: J Clin Invest
May 2013

The liver has a unique and extraordinary capacity for regeneration, even in adult organisms. This regenerative potential has traditionally been attributed to the replicative capabilities of mature hepatocytes and cholangiocytes, though emerging evidence suggests that other resident liver cell types such as progenitors, liver sinusoidal endothelial cells, and hepatic stellate cells respond to liver injury and contribute to repair. These other cells types are also associated with liver scarring, dysfunction, and carcinogenesis, which suggests that appropriate regulation of these cells is a major determinant of response to liver injury. The Reviews in this series explore possible contributions of liver progenitor cells, liver sinusoidal endothelial cells, and hepatic stellate cells to liver homeostasis and repair and highlight how these processes can go awry in chronic liver injury, fibrosis, and liver cancer.

Duke Scholars

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

May 2013

Volume

123

Issue

5

Start / End Page

1858 / 1860

Location

United States

Related Subject Headings

  • Wound Healing
  • Stem Cells
  • Liver Regeneration
  • Liver Neoplasms
  • Liver Diseases
  • Liver Cirrhosis
  • Liver
  • Immunology
  • Humans
  • Hepatocytes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Diehl, A. M., & Chute, J. (2013). Underlying potential: cellular and molecular determinants of adult liver repair. J Clin Invest, 123(5), 1858–1860. https://doi.org/10.1172/JCI69966
Diehl, Anna Mae, and John Chute. “Underlying potential: cellular and molecular determinants of adult liver repair.J Clin Invest 123, no. 5 (May 2013): 1858–60. https://doi.org/10.1172/JCI69966.
Diehl AM, Chute J. Underlying potential: cellular and molecular determinants of adult liver repair. J Clin Invest. 2013 May;123(5):1858–60.
Diehl, Anna Mae, and John Chute. “Underlying potential: cellular and molecular determinants of adult liver repair.J Clin Invest, vol. 123, no. 5, May 2013, pp. 1858–60. Pubmed, doi:10.1172/JCI69966.
Diehl AM, Chute J. Underlying potential: cellular and molecular determinants of adult liver repair. J Clin Invest. 2013 May;123(5):1858–1860.

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

May 2013

Volume

123

Issue

5

Start / End Page

1858 / 1860

Location

United States

Related Subject Headings

  • Wound Healing
  • Stem Cells
  • Liver Regeneration
  • Liver Neoplasms
  • Liver Diseases
  • Liver Cirrhosis
  • Liver
  • Immunology
  • Humans
  • Hepatocytes