Beyond symmetry-breaking: competition and negative feedback in GTPase regulation.

Published

Journal Article (Review)

Cortical domains are often specified by the local accumulation of active GTPases. Such domains can arise through spontaneous symmetry-breaking, suggesting that GTPase accumulation occurs via positive feedback. Here, we focus on recent advances in fungal and plant cell models - where new work suggests that polarity-controlling GTPases develop only one 'front' because GTPase clusters engage in a winner-takes-all competition. However, in some circumstances two or more GTPase domains can coexist, and the basis for the switch from competition to coexistence remains an open question. Polarity GTPases can undergo oscillatory clustering and dispersal, suggesting that these systems contain negative feedback. Negative feedback may prevent polarity clusters from spreading too far, regulate the balance between competition and coexistence, and provide directional flexibility for cells tracking gradients.

Full Text

Duke Authors

Cited Authors

  • Wu, C-F; Lew, DJ

Published Date

  • October 2013

Published In

Volume / Issue

  • 23 / 10

Start / End Page

  • 476 - 483

PubMed ID

  • 23731999

Pubmed Central ID

  • 23731999

Electronic International Standard Serial Number (EISSN)

  • 1879-3088

Digital Object Identifier (DOI)

  • 10.1016/j.tcb.2013.05.003

Language

  • eng

Conference Location

  • England