Alterations in neurotrophins and neurotrophin receptors in Alzheimer's disease.


Journal Article

We demonstrated that nerve growth factor (NGF) levels were increased in hippocampus and cortical areas, as well as in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). Such increases may, at least in part, be due to a decreased expression of the NGF high affinity receptor trkA. Measurement of CSF levels of NGF may add to the repertoire of potential biochemical diagnostic markers in living AD patients.

Full Text

Cited Authors

  • Hock, CH; Heese, K; Olivieri, G; Hulette, CH; Rosenberg, C; Nitsch, RM; Otten, U

Published Date

  • 2000

Published In

Volume / Issue

  • 59 /

Start / End Page

  • 171 - 174

PubMed ID

  • 10961429

Pubmed Central ID

  • 10961429

International Standard Serial Number (ISSN)

  • 0303-6995

Digital Object Identifier (DOI)

  • 10.1007/978-3-7091-6781-6_19


  • eng

Conference Location

  • Austria