Hypofractionation for clinically localized prostate cancer.

Journal Article (Review)

This manuscript reviews the clinical evidence for hypofractionation in prostate cancer, focusing on data from prospective trials. For the purposes of this manuscript, we categorize hypofractionation as moderate (2.4-4 Gy per fraction) or extreme (6.5-10 Gy per fraction). Five randomized controlled trials have evaluated moderate hypofractionation in >1500 men, with most followed for >4-5 years. The results of these randomized trials are inconsistent. No randomized trials or other rigorous comparisons of extreme hypofractionation with conventional fractionation have been reported. Prospective single-arm studies of extreme hypofractionation appear favorable, but small sample sizes preclude precise estimates of efficacy and short follow-up prevents complication estimates beyond 3-5 years. Over the next several years, the results of 3 large noninferiority trials of moderate hypofractionation and 2 randomized trials of extreme hypofractionation should help clarify the role of hypofractionation in prostate cancer therapy.

Full Text

Duke Authors

Cited Authors

  • Cabrera, AR; Lee, WR

Published Date

  • July 2013

Published In

Volume / Issue

  • 23 / 3

Start / End Page

  • 191 - 197

PubMed ID

  • 23763885

Pubmed Central ID

  • 23763885

Electronic International Standard Serial Number (EISSN)

  • 1532-9461

Digital Object Identifier (DOI)

  • 10.1016/j.semradonc.2013.01.005


  • eng

Conference Location

  • United States