Hereditary progressive atrioventricular conduction defect.

Journal Article (Journal Article)

New data on genetics, including an extensive pedigree and certain aspects of natural history, have been compiled on Family S, which is characterized by a hereditary progressive atrioventricular (A-V) conduction defect. Concordance analysis of heart block in affected parents and their offspring suggests as a working hypothesis transmission of diathesis for the defect by means of a Mendelian autosomal dominant factor. Regression of the defect in several relatives, including reversion from first degree heart block to normal A-V conduction, defies explanation at this time. However, rapport established with the unusually large (1,067 members) and cooperative kindred will permit longitudinal evaluation of these findings.

Full Text

Duke Authors

Cited Authors

  • Lynch, HT; Mohiuddin, S; Moran, J; Kaplan, A; Sketch, M; Zencka, A; Runco, V

Published Date

  • September 1, 1975

Published In

Volume / Issue

  • 36 / 3

Start / End Page

  • 297 - 301

PubMed ID

  • 1166834

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/0002-9149(75)90479-8


  • eng

Conference Location

  • United States