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Hereditary progressive atrioventricular conduction defect.

Publication ,  Journal Article
Lynch, HT; Mohiuddin, S; Moran, J; Kaplan, A; Sketch, M; Zencka, A; Runco, V
Published in: Am J Cardiol
September 1975

New data on genetics, including an extensive pedigree and certain aspects of natural history, have been compiled on Family S, which is characterized by a hereditary progressive atrioventricular (A-V) conduction defect. Concordance analysis of heart block in affected parents and their offspring suggests as a working hypothesis transmission of diathesis for the defect by means of a Mendelian autosomal dominant factor. Regression of the defect in several relatives, including reversion from first degree heart block to normal A-V conduction, defies explanation at this time. However, rapport established with the unusually large (1,067 members) and cooperative kindred will permit longitudinal evaluation of these findings.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

September 1975

Volume

36

Issue

3

Start / End Page

297 / 301

Location

United States

Related Subject Headings

  • Sex Factors
  • Risk
  • Pedigree
  • Male
  • Humans
  • Heart Conduction System
  • Heart Block
  • Genes, Dominant
  • Female
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
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Lynch, H. T., Mohiuddin, S., Moran, J., Kaplan, A., Sketch, M., Zencka, A., & Runco, V. (1975). Hereditary progressive atrioventricular conduction defect. Am J Cardiol, 36(3), 297–301. https://doi.org/10.1016/0002-9149(75)90479-8
Lynch, H. T., S. Mohiuddin, J. Moran, A. Kaplan, M. Sketch, A. Zencka, and V. Runco. “Hereditary progressive atrioventricular conduction defect.Am J Cardiol 36, no. 3 (September 1975): 297–301. https://doi.org/10.1016/0002-9149(75)90479-8.
Lynch HT, Mohiuddin S, Moran J, Kaplan A, Sketch M, Zencka A, et al. Hereditary progressive atrioventricular conduction defect. Am J Cardiol. 1975 Sep;36(3):297–301.
Lynch, H. T., et al. “Hereditary progressive atrioventricular conduction defect.Am J Cardiol, vol. 36, no. 3, Sept. 1975, pp. 297–301. Pubmed, doi:10.1016/0002-9149(75)90479-8.
Lynch HT, Mohiuddin S, Moran J, Kaplan A, Sketch M, Zencka A, Runco V. Hereditary progressive atrioventricular conduction defect. Am J Cardiol. 1975 Sep;36(3):297–301.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

September 1975

Volume

36

Issue

3

Start / End Page

297 / 301

Location

United States

Related Subject Headings

  • Sex Factors
  • Risk
  • Pedigree
  • Male
  • Humans
  • Heart Conduction System
  • Heart Block
  • Genes, Dominant
  • Female
  • Child