Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.

Published

Journal Article

To test if knowledge of type 2 diabetes genetic variants improves disease prediction.We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regression models stratified by age (<50 years, diabetes cases = 144; or ≥50 years, diabetes cases = 302). Models included clinical risk factors and a 40-SNP weighted genetic risk score.In people <50 years of age, the clinical risk factors model C-statistic was 0.908; the 40-SNP score increased it to 0.911 (P = 0.3; net reclassification improvement (NRI): 10.2%, P = 0.001). In people ≥50 years of age, the C-statistics without and with the score were 0.883 and 0.884 (P = 0.2; NRI: 0.4%). The risk per risk allele was higher in people <50 than ≥50 years of age (24 vs. 11%; P value for age interaction = 0.02).Knowledge of common genetic variation appropriately reclassifies younger people for type 2 diabetes risk beyond clinical risk factors but not older people.

Full Text

Duke Authors

Cited Authors

  • de Miguel-Yanes, JM; Shrader, P; Pencina, MJ; Fox, CS; Manning, AK; Grant, RW; Dupuis, J; Florez, JC; D'Agostino, RB; Cupples, LA; Meigs, JB; MAGIC Investigators, ; DIAGRAM+ Investigators,

Published Date

  • January 2011

Published In

Volume / Issue

  • 34 / 1

Start / End Page

  • 121 - 125

PubMed ID

  • 20889853

Pubmed Central ID

  • 20889853

Electronic International Standard Serial Number (EISSN)

  • 1935-5548

International Standard Serial Number (ISSN)

  • 0149-5992

Digital Object Identifier (DOI)

  • 10.2337/dc10-1265

Language

  • eng