Prevalence, clinical correlates, and prognosis of discrete upper septal thickening on echocardiography: the Framingham Heart Study.


Journal Article

The upper interventricular septum may be prominent in elderly individuals, a finding referred to as discrete upper septal thickening (DUST). We examined the prevalence, clinical and echocardiographic correlates, and prognostic significance of DUST in a community-based sample. We evaluated Framingham Study participants who underwent routine echocardiography. In 3562 Framingham Study participants (mean age 58 years, 57% women), DUST was observed in 52 participants. The clinical correlates of DUST were increasing age (odds ratio [OR] per 10 year increment 2.59, 95% confidence intervals [CI] 1.64-4.08) and systolic blood pressure (OR per SD increment 1.55, 95% CI 1.15-2.09). DUST was positively associated with left ventricular (LV) fractional shortening and mitral annular calcification but inversely with LV diastolic dimensions (P < 0.02 for all). On follow-up (mean 15 years), 732 individuals died (33 with DUST) and 560 experienced a cardiovascular disease (CVD) event (18 with DUST). Adjusting for cardiovascular risk factors, DUST was not associated with CVD or mortality risk (P > 0.30 for both). The follow-up component of our study suggests that DUST is not independently associated with adverse prognosis.

Full Text

Duke Authors

Cited Authors

  • Diaz, T; Pencina, MJ; Benjamin, EJ; Aragam, J; Fuller, DL; Pencina, KM; Levy, D; Vasan, RS

Published Date

  • March 2009

Published In

Volume / Issue

  • 26 / 3

Start / End Page

  • 247 - 253

PubMed ID

  • 19175779

Pubmed Central ID

  • 19175779

Electronic International Standard Serial Number (EISSN)

  • 1540-8175

Digital Object Identifier (DOI)

  • 10.1111/j.1540-8175.2008.00806.x


  • eng

Conference Location

  • United States