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Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample.

Publication ,  Journal Article
Fox, CS; Pencina, MJ; D'Agostino, RB; Murabito, JM; Seely, EW; Pearce, EN; Vasan, RS
Published in: Arch Intern Med
March 24, 2008

BACKGROUND: Overt hypothyroidism and hyperthyroidism may be associated with weight gain and loss. We assessed whether variations in thyroid function within the reference (physiologic) range are associated with body weight. METHODS: Framingham Offspring Study participants (n=2407) who attended 2 consecutive routine examinations, were not receiving thyroid hormone therapy, and had baseline serum thyrotropin (TSH) concentrations of 0.5 to 5.0 mIU/L and follow-up concentrations of 0.5 to 10.0 mIU/L were included in this study. Baseline TSH concentrations were related to body weight and body weight change during 3.5 years of follow-up. RESULTS: At baseline, adjusted mean weight increased progressively from 64.5 to 70.2 kg in the lowest to highest TSH concentration quartiles in women (P< .001 for trend), and from 82.8 (lowest quartile) to 85.6 kg (highest quartile) in men (P= .007 for trend). During 3.5 years of follow-up, mean (SD) body weight increased by 1.5 (5.6) kg in women and 1.0 (5.0) kg in men. Baseline TSH concentrations were not associated with weight change during follow-up. However, an increase in TSH concentration at follow-up was positively associated with weight gain in women (0.5-2.3 kg across increasing quartiles of TSH concentration change; P< .001 for trend) and men (0.4-1.3 kg across quartiles of TSH concentration change; P= .007 for trend). CONCLUSIONS: Thyroid function (as assessed by serum TSH concentration) within the reference range is associated with body weight in both sexes. Our findings raise the possibility that modest increases in serum TSH concentrations within the reference range may be associated with weight gain.

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Published In

Arch Intern Med

DOI

ISSN

0003-9926

Publication Date

March 24, 2008

Volume

168

Issue

6

Start / End Page

587 / 592

Location

United States

Related Subject Headings

  • Weight Loss
  • Weight Gain
  • Thyrotropin
  • Thyroid Gland
  • Reference Values
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • General & Internal Medicine
 

Citation

APA
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ICMJE
MLA
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Fox, C. S., Pencina, M. J., D’Agostino, R. B., Murabito, J. M., Seely, E. W., Pearce, E. N., & Vasan, R. S. (2008). Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample. Arch Intern Med, 168(6), 587–592. https://doi.org/10.1001/archinte.168.6.587
Fox, Caroline S., Michael J. Pencina, Ralph B. D’Agostino, Joanne M. Murabito, Ellen W. Seely, Elizabeth N. Pearce, and Ramachandran S. Vasan. “Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample.Arch Intern Med 168, no. 6 (March 24, 2008): 587–92. https://doi.org/10.1001/archinte.168.6.587.
Fox CS, Pencina MJ, D’Agostino RB, Murabito JM, Seely EW, Pearce EN, et al. Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample. Arch Intern Med. 2008 Mar 24;168(6):587–92.
Fox, Caroline S., et al. “Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample.Arch Intern Med, vol. 168, no. 6, Mar. 2008, pp. 587–92. Pubmed, doi:10.1001/archinte.168.6.587.
Fox CS, Pencina MJ, D’Agostino RB, Murabito JM, Seely EW, Pearce EN, Vasan RS. Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample. Arch Intern Med. 2008 Mar 24;168(6):587–592.

Published In

Arch Intern Med

DOI

ISSN

0003-9926

Publication Date

March 24, 2008

Volume

168

Issue

6

Start / End Page

587 / 592

Location

United States

Related Subject Headings

  • Weight Loss
  • Weight Gain
  • Thyrotropin
  • Thyroid Gland
  • Reference Values
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • General & Internal Medicine