Skip to main content
Journal cover image

Cardiovascular risk factors predictive for survival and morbidity-free survival in the oldest-old Framingham Heart Study participants.

Publication ,  Journal Article
Terry, DF; Pencina, MJ; Vasan, RS; Murabito, JM; Wolf, PA; Hayes, MK; Levy, D; D'Agostino, RB; Benjamin, EJ
Published in: J Am Geriatr Soc
November 2005

OBJECTIVES: To examine whether midlife cardiovascular risk factors predict survival and survival free of major comorbidities to the age of 85. DESIGN: Prospective community-based cohort study. SETTING: Framingham Heart Study, Massachusetts. PARTICIPANTS: Two thousand five hundred thirty-one individuals (1,422 women) who attended at least two examinations between the ages of 40 and 50. MEASUREMENTS: Risk factors were classified at routine examinations performed between the ages of 40 and 50. Stepwise sex-adjusted logistic regression models predicting the outcomes of survival and survival free of morbidity to age 85 were selected from the following risk factors: systolic and diastolic blood pressure, total serum cholesterol, glucose intolerance, cigarette smoking, education, body mass index, physical activity index, pulse pressure, antihypertensive medication, and electrocardiographic left ventricular hypertrophy. RESULTS: More than one-third of the study sample survived to age 85, and 22% of the original study sample survived free of morbidity. Lower midlife blood pressure and total cholesterol levels, absence of glucose intolerance, nonsmoking status, higher educational attainment, and female sex predicted overall and morbidity-free survival. The predicted probability of survival to age 85 fell in the presence of accumulating risk factors: 37% for men with no risk factors to 2% with all five risk factors and 65% for women with no risk factors to 14% with all five risk factors. CONCLUSION: Lower levels of key cardiovascular risk factors in middle age predicted overall survival and major morbidity-free survival to age 85. Recognizing and modifying these factors may delay, if not prevent, age-related morbidity and mortality.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

November 2005

Volume

53

Issue

11

Start / End Page

1944 / 1950

Location

United States

Related Subject Headings

  • Survival Analysis
  • Risk Factors
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Health Knowledge, Attitudes, Practice
  • Health Behavior
  • Geriatrics
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Terry, D. F., Pencina, M. J., Vasan, R. S., Murabito, J. M., Wolf, P. A., Hayes, M. K., … Benjamin, E. J. (2005). Cardiovascular risk factors predictive for survival and morbidity-free survival in the oldest-old Framingham Heart Study participants. J Am Geriatr Soc, 53(11), 1944–1950. https://doi.org/10.1111/j.1532-5415.2005.00465.x
Terry, Dellara F., Michael J. Pencina, Ramachandran S. Vasan, Joanne M. Murabito, Philip A. Wolf, Margaret Kelly Hayes, Daniel Levy, Ralph B. D’Agostino, and Emelia J. Benjamin. “Cardiovascular risk factors predictive for survival and morbidity-free survival in the oldest-old Framingham Heart Study participants.J Am Geriatr Soc 53, no. 11 (November 2005): 1944–50. https://doi.org/10.1111/j.1532-5415.2005.00465.x.
Terry DF, Pencina MJ, Vasan RS, Murabito JM, Wolf PA, Hayes MK, et al. Cardiovascular risk factors predictive for survival and morbidity-free survival in the oldest-old Framingham Heart Study participants. J Am Geriatr Soc. 2005 Nov;53(11):1944–50.
Terry, Dellara F., et al. “Cardiovascular risk factors predictive for survival and morbidity-free survival in the oldest-old Framingham Heart Study participants.J Am Geriatr Soc, vol. 53, no. 11, Nov. 2005, pp. 1944–50. Pubmed, doi:10.1111/j.1532-5415.2005.00465.x.
Terry DF, Pencina MJ, Vasan RS, Murabito JM, Wolf PA, Hayes MK, Levy D, D’Agostino RB, Benjamin EJ. Cardiovascular risk factors predictive for survival and morbidity-free survival in the oldest-old Framingham Heart Study participants. J Am Geriatr Soc. 2005 Nov;53(11):1944–1950.
Journal cover image

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

November 2005

Volume

53

Issue

11

Start / End Page

1944 / 1950

Location

United States

Related Subject Headings

  • Survival Analysis
  • Risk Factors
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Health Knowledge, Attitudes, Practice
  • Health Behavior
  • Geriatrics
  • Female