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Cross-sectional relations of urinary sodium excretion to cardiac structure and hypertrophy. The Framingham Heart Study.

Publication ,  Journal Article
Dhingra, R; Pencina, MJ; Benjamin, EJ; Levy, D; Larson, MG; Meigs, JB; Rifai, N; D'Agostino, RB; Vasan, RS
Published in: Am J Hypertens
October 2004

BACKGROUND: Increased sodium intake has been positively associated with high blood pressure (BP) and hypertensive target organ damage, but associations with cardiac structure in nonhypertensive individuals have yielded inconsistent results. We tested the hypothesis that sodium intake is associated with left ventricular (LV) mass and left ventricular hypertrophy (LVH), independent of BP, in the community. METHODS: We analyzed the cross-sectional relationships between urinary sodium excretion and LV measurements in a community-based sample of 2660 Framingham Offspring Study participants (mean age 58 years, 56% women and 44% men). Participants with known coronary artery disease, congestive heart failure, or renal failure as well as those using diuretics were excluded. Urinary sodium excretion was measured on a spot urine sample and was indexed to urinary creatinine. RESULTS: In sex-specific, multivariable linear regression models adjusting for covariates known to influence LV measurements, log urinary sodium was not associated with LV mass, wall thickness, end-diastolic dimensions, or left atrial size in either sex. Urinary sodium was not related to LVH defined as LV mass >/= sex-specific 80th percentile value. In analyses restricted to hypertensive individuals (n = 983, 470 women), urinary sodium was not associated with LV mass or LVH. CONCLUSIONS: In our large community-based sample, urinary sodium excretion was not related to LV mass, function, or hypertrophy.

Duke Scholars

Published In

Am J Hypertens

DOI

ISSN

0895-7061

Publication Date

October 2004

Volume

17

Issue

10

Start / End Page

891 / 896

Location

United States

Related Subject Headings

  • Natriuresis
  • Middle Aged
  • Male
  • Linear Models
  • Hypertrophy, Left Ventricular
  • Humans
  • Female
  • Echocardiography, Doppler, Color
  • Echocardiography
  • Cross-Sectional Studies
 

Citation

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Dhingra, R., Pencina, M. J., Benjamin, E. J., Levy, D., Larson, M. G., Meigs, J. B., … Vasan, R. S. (2004). Cross-sectional relations of urinary sodium excretion to cardiac structure and hypertrophy. The Framingham Heart Study. Am J Hypertens, 17(10), 891–896. https://doi.org/10.1016/j.amjhyper.2004.06.008
Dhingra, Ravi, Michael J. Pencina, Emelia J. Benjamin, Daniel Levy, Martin G. Larson, James B. Meigs, Nader Rifai, Ralph B. D’Agostino, and Ramachandran S. Vasan. “Cross-sectional relations of urinary sodium excretion to cardiac structure and hypertrophy. The Framingham Heart Study.Am J Hypertens 17, no. 10 (October 2004): 891–96. https://doi.org/10.1016/j.amjhyper.2004.06.008.
Dhingra R, Pencina MJ, Benjamin EJ, Levy D, Larson MG, Meigs JB, et al. Cross-sectional relations of urinary sodium excretion to cardiac structure and hypertrophy. The Framingham Heart Study. Am J Hypertens. 2004 Oct;17(10):891–6.
Dhingra, Ravi, et al. “Cross-sectional relations of urinary sodium excretion to cardiac structure and hypertrophy. The Framingham Heart Study.Am J Hypertens, vol. 17, no. 10, Oct. 2004, pp. 891–96. Pubmed, doi:10.1016/j.amjhyper.2004.06.008.
Dhingra R, Pencina MJ, Benjamin EJ, Levy D, Larson MG, Meigs JB, Rifai N, D’Agostino RB, Vasan RS. Cross-sectional relations of urinary sodium excretion to cardiac structure and hypertrophy. The Framingham Heart Study. Am J Hypertens. 2004 Oct;17(10):891–896.
Journal cover image

Published In

Am J Hypertens

DOI

ISSN

0895-7061

Publication Date

October 2004

Volume

17

Issue

10

Start / End Page

891 / 896

Location

United States

Related Subject Headings

  • Natriuresis
  • Middle Aged
  • Male
  • Linear Models
  • Hypertrophy, Left Ventricular
  • Humans
  • Female
  • Echocardiography, Doppler, Color
  • Echocardiography
  • Cross-Sectional Studies