Skip to main content

Detection of hepatic lesions in candidates for surgery: comparison of ferumoxides-enhanced MR imaging and dual-phase helical CT.

Publication ,  Journal Article
Bluemke, DA; Paulson, EK; Choti, MA; DeSena, S; Clavien, PA
Published in: AJR Am J Roentgenol
December 2000

OBJECTIVE: The purpose of this study was to compare the use of phased array MR imaging of the liver at 1.5 T with and without ferumoxides with dual-phase helical CT for the detection of hepatic lesions in candidates for hepatic surgery. SUBJECTS AND METHODS: Patients with known or suspected hepatic lesions who were eligible for surgery underwent dual-phase helical CT at 20 and 70 sec after the start of contrast material injection and phased array MR imaging using fast spin-echo T2-weighted imaging and gradient-echo T1-weighted imaging before and after ferumoxides infusion of 0.56 mg of iron per kilogram of body weight. Three observers who were unaware of the surgical findings separately reviewed the CT scans and unenhanced and enhanced MR images of 24 patients who completed the protocol. The observers' findings were compared with results obtained at surgery using intraoperative sonography and having histopathologic confirmation. Statistical analysis was performed using a segment-by-segment analysis. RESULTS: Eighty-two lesions were found at surgery. The sensitivity of CT, unenhanced MR imaging, and enhanced MR imaging for blinded observers was 60.4%, 62.0%, and 68.2%, respectively. The specificity was 89.2%, 81.9%, and 81.6%, respectively. Five lesions in three patients were not detected preoperatively using any of the techniques. MR imaging found additional lesions not detected on CT in four patients; CT detected one additional lesion not seen on MR imaging. CONCLUSION: Ferumoxides-enhanced MR imaging of the liver shows a trend toward increased sensitivity compared with dual-phase helical CT. Specificity of helical CT was superior to that of enhanced MR imaging for most observers.

Duke Scholars

Published In

AJR Am J Roentgenol

DOI

ISSN

0361-803X

Publication Date

December 2000

Volume

175

Issue

6

Start / End Page

1653 / 1658

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Suspensions
  • Sensitivity and Specificity
  • Oxides
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetite Nanoparticles
  • Magnetic Resonance Imaging
  • Liver Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bluemke, D. A., Paulson, E. K., Choti, M. A., DeSena, S., & Clavien, P. A. (2000). Detection of hepatic lesions in candidates for surgery: comparison of ferumoxides-enhanced MR imaging and dual-phase helical CT. AJR Am J Roentgenol, 175(6), 1653–1658. https://doi.org/10.2214/ajr.175.6.1751653
Bluemke, D. A., E. K. Paulson, M. A. Choti, S. DeSena, and P. A. Clavien. “Detection of hepatic lesions in candidates for surgery: comparison of ferumoxides-enhanced MR imaging and dual-phase helical CT.AJR Am J Roentgenol 175, no. 6 (December 2000): 1653–58. https://doi.org/10.2214/ajr.175.6.1751653.
Bluemke DA, Paulson EK, Choti MA, DeSena S, Clavien PA. Detection of hepatic lesions in candidates for surgery: comparison of ferumoxides-enhanced MR imaging and dual-phase helical CT. AJR Am J Roentgenol. 2000 Dec;175(6):1653–8.
Bluemke, D. A., et al. “Detection of hepatic lesions in candidates for surgery: comparison of ferumoxides-enhanced MR imaging and dual-phase helical CT.AJR Am J Roentgenol, vol. 175, no. 6, Dec. 2000, pp. 1653–58. Pubmed, doi:10.2214/ajr.175.6.1751653.
Bluemke DA, Paulson EK, Choti MA, DeSena S, Clavien PA. Detection of hepatic lesions in candidates for surgery: comparison of ferumoxides-enhanced MR imaging and dual-phase helical CT. AJR Am J Roentgenol. 2000 Dec;175(6):1653–1658.

Published In

AJR Am J Roentgenol

DOI

ISSN

0361-803X

Publication Date

December 2000

Volume

175

Issue

6

Start / End Page

1653 / 1658

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Suspensions
  • Sensitivity and Specificity
  • Oxides
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetite Nanoparticles
  • Magnetic Resonance Imaging
  • Liver Neoplasms