Testis formation in the fetal mouse: dynamic and complex de novo tubulogenesis.


Journal Article (Review)

Soon after Sry initiates male sex determination, cells in XY gonads undergo an unusual process of de novo cord formation that results in the organization of Sertoli cells into epithelial tubules enclosing germ cells and partitioning mesenchymal cells and vasculature to the interstitial space of the testis. Recent experiments investigating this dynamic process in four dimensions have begun to shed new light on the collective interactions of multiple cell types during morphogenesis of testis cords.

Full Text

Duke Authors

Cited Authors

  • Cool, J; DeFalco, T; Capel, B

Published Date

  • November 2012

Published In

Volume / Issue

  • 1 / 6

Start / End Page

  • 847 - 859

PubMed ID

  • 23799626

Pubmed Central ID

  • 23799626

Electronic International Standard Serial Number (EISSN)

  • 1759-7692

Digital Object Identifier (DOI)

  • 10.1002/wdev.62


  • eng

Conference Location

  • United States