Regulation of iron transport related genes by boron in the marine bacterium Marinobacter algicola DG893.
While there has been extensive interest in the use of boron isotope ratios as a surrogate of pH in paleoclimate studies in the context of climate change-related questions, the high (0.4 mM) concentration and the depth-independent (conservative or non-nutrient-like) concentration profile of this element have led to boron being neglected as a potentially biologically relevant element in the modern ocean. Here we report that boron affects the expression of a number of protein and genes in the "algal-associated" Gram-negative marine bacterium Marinobacter algicola DG893. Most intriguingly, a number of these proteins and genes are related to iron uptake. In a recent separate publication we have shown that boron regulates one such iron transport related protein, i.e. the periplasmic iron binding protein FbpA via a direct interaction of the metalloid with this protein. Here we show that a number of other iron uptake related genes are also affected by boron but in the opposite way i.e. they are up-regulated. We propose that the differential effect of boron on FbpA expression relative to other iron transport related genes is a result of an interaction between boron and the global iron regulatory protein Fur.
Duke Scholars
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Related Subject Headings
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Repressor Proteins
- Proteome
- Periplasmic Binding Proteins
- Marinobacter
- Iron
- Hydrogen-Ion Concentration
- Gene Expression Regulation, Bacterial
- Gene Expression Profiling
- Boron
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Repressor Proteins
- Proteome
- Periplasmic Binding Proteins
- Marinobacter
- Iron
- Hydrogen-Ion Concentration
- Gene Expression Regulation, Bacterial
- Gene Expression Profiling
- Boron