Skip to main content

Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL.

Publication ,  Journal Article
Richards, KL; Motsinger-Reif, AA; Chen, H-W; Fedoriw, Y; Fan, C; Nielsen, DM; Small, GW; Thomas, R; Smith, C; Dave, SS; Perou, CM; Breen, M ...
Published in: Cancer Res
August 15, 2013

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype, and fewer than half of patients are cured with standard first-line therapy. To improve therapeutic options, better animal models that accurately mimic human DLBCL (hDLBCL) are needed. Canine DLBCL, one of the most common cancers in veterinary oncology, is morphologically similar to hDLBCL and is treated using similar chemotherapeutic protocols. With genomic technologies, it is now possible to molecularly evaluate dogs as a potential large-animal model for hDLBCL. We evaluated canine B-cell lymphomas (cBCL) using immunohistochemistry (IHC) and gene expression profiling. cBCL expression profiles were similar in many ways to hDLBCLs. For instance, a subset had increased expression of NF-κB pathway genes, mirroring human activated B-cell (ABC)-type DLBCL. Furthermore, immunoglobulin heavy chain ongoing mutation status, which is correlated with ABC/germinal center B-cell cell of origin in hDLBCL, separated cBCL into two groups with statistically different progression-free and overall survival times. In contrast with hDLBCL, cBCL rarely expressed BCL6 and MUM1/IRF4 by IHC. Collectively, these studies identify molecular similarities to hDLBCL that introduce pet dogs as a representative model of hDLBCL for future studies, including therapeutic clinical trials.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

August 15, 2013

Volume

73

Issue

16

Start / End Page

5029 / 5039

Location

United States

Related Subject Headings

  • Transcriptome
  • Proto-Oncogene Proteins c-bcl-6
  • Oncology & Carcinogenesis
  • NF-kappa B
  • Mutation
  • Male
  • Lymphoma, Large B-Cell, Diffuse
  • Lymphoma, B-Cell
  • Lymph Nodes
  • Interferon Regulatory Factors
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Richards, K. L., Motsinger-Reif, A. A., Chen, H.-W., Fedoriw, Y., Fan, C., Nielsen, D. M., … Suter, S. E. (2013). Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL. Cancer Res, 73(16), 5029–5039. https://doi.org/10.1158/0008-5472.CAN-12-3546
Richards, Kristy L., Alison A. Motsinger-Reif, Hsiao-Wei Chen, Yuri Fedoriw, Cheng Fan, Dahlia M. Nielsen, George W. Small, et al. “Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL.Cancer Res 73, no. 16 (August 15, 2013): 5029–39. https://doi.org/10.1158/0008-5472.CAN-12-3546.
Richards KL, Motsinger-Reif AA, Chen H-W, Fedoriw Y, Fan C, Nielsen DM, et al. Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL. Cancer Res. 2013 Aug 15;73(16):5029–39.
Richards, Kristy L., et al. “Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL.Cancer Res, vol. 73, no. 16, Aug. 2013, pp. 5029–39. Pubmed, doi:10.1158/0008-5472.CAN-12-3546.
Richards KL, Motsinger-Reif AA, Chen H-W, Fedoriw Y, Fan C, Nielsen DM, Small GW, Thomas R, Smith C, Dave SS, Perou CM, Breen M, Borst LB, Suter SE. Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL. Cancer Res. 2013 Aug 15;73(16):5029–5039.

Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

August 15, 2013

Volume

73

Issue

16

Start / End Page

5029 / 5039

Location

United States

Related Subject Headings

  • Transcriptome
  • Proto-Oncogene Proteins c-bcl-6
  • Oncology & Carcinogenesis
  • NF-kappa B
  • Mutation
  • Male
  • Lymphoma, Large B-Cell, Diffuse
  • Lymphoma, B-Cell
  • Lymph Nodes
  • Interferon Regulatory Factors