On model specification and selection of the Cox proportional hazards model.

Journal Article (Journal Article)

Prognosis plays a pivotal role in patient management and trial design. A useful prognostic model should correctly identify important risk factors and estimate their effects. In this article, we discuss several challenges in selecting prognostic factors and estimating their effects using the Cox proportional hazards model. Although a flexible semiparametric form, the Cox's model is not entirely exempt from model misspecification. To minimize possible misspecification, instead of imposing traditional linear assumption, flexible modeling techniques have been proposed to accommodate the nonlinear effect. We first review several existing nonparametric estimation and selection procedures and then present a numerical study to compare the performance between parametric and nonparametric procedures. We demonstrate the impact of model misspecification on variable selection and model prediction using a simulation study and an example from a phase III trial in prostate cancer.

Full Text

Duke Authors

Cited Authors

  • Lin, C-Y; Halabi, S

Published Date

  • November 20, 2013

Published In

Volume / Issue

  • 32 / 26

Start / End Page

  • 4609 - 4623

PubMed ID

  • 23784939

Pubmed Central ID

  • 23784939

Electronic International Standard Serial Number (EISSN)

  • 1097-0258

Digital Object Identifier (DOI)

  • 10.1002/sim.5876


  • eng

Conference Location

  • England