Radiation Therapy in Anal and Rectal Cancer

Journal Article

Historically, squamous cell carcinoma of the anal canal was treated with abdominoperineal resection. Nigro discovered that radiation therapy combined with 5-fluorouracil and mitomycin resulted in high rates of local control and colostomy-free and overall survival without surgical intervention. Recent advances include the integration of PET into staging, radiation treatment planning, disease monitoring, and the use of intensity-modulated radiation therapy. For rectal cancer, clinical trials have established the role for neoadjuvant therapy for T3-4 and/or node-positive tumor presentations. Chemotherapy and targeted agents are under study in both anal and rectal cancers to improve on the standard combinations of chemotherapy and radiation. © 2013 Elsevier Inc.

Full Text

Duke Authors

Cited Authors

  • Czito, BG; Meyer, J

Published Date

  • 2013

Published In

Volume / Issue

  • 22 / 3

Start / End Page

  • 525 - 543

International Standard Serial Number (ISSN)

  • 1055-3207

Digital Object Identifier (DOI)

  • 10.1016/j.soc.2013.02.010