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Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor

Publication ,  Journal Article
Yu, B; Shah, A; Wang, B; Rajaram, N; Wang, Q; Ramanujam, N; Palmer, GM; Dewhirst, MW
Published in: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
May 27, 2013

Many studies have found that hypoxia, particularly cycling hypoxia (CH), can lead to enhanced tumor metastasis and resistance to radiation and chemotherapy. It was also reported that tumor total hemoglobin content (THb), which is directly related to tumor angiogenesis, can have significant impact on tumor's response to radiation and neoadjuvant chemotherapy. There is a growing demand for technologies to measure tumor hypoxia and angiogenesis temporally in vivo. In this paper, a side-firing fiber optic sensor based on a multi-wavelength frequency-domain near infrared spectroscopy (FD-NIRS) instrument was used to quantify tumor oxygenation and hemoglobin concentrations in nude rats bearing human FaDu head and neck (H & N) tumors during normoxia and forced hyperoxia and cyclic hypoxia. Significant increase (with carbogen gas inhalation) or decrease (with reduced O2 supply) in tumor oxygenation was observed. The studies demonstrated the feasibility of the technology for longitudinal monitoring of H and N tumor's response to therapy. © 2013 Copyright SPIE.

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Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

Publication Date

May 27, 2013

Volume

8578
 

Citation

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Yu, B., Shah, A., Wang, B., Rajaram, N., Wang, Q., Ramanujam, N., … Dewhirst, M. W. (2013). Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8578. https://doi.org/10.1117/12.2002837
Yu, B., A. Shah, B. Wang, N. Rajaram, Q. Wang, N. Ramanujam, G. M. Palmer, and M. W. Dewhirst. “Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8578 (May 27, 2013). https://doi.org/10.1117/12.2002837.
Yu B, Shah A, Wang B, Rajaram N, Wang Q, Ramanujam N, et al. Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2013 May 27;8578.
Yu, B., et al. “Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8578, May 2013. Scopus, doi:10.1117/12.2002837.
Yu B, Shah A, Wang B, Rajaram N, Wang Q, Ramanujam N, Palmer GM, Dewhirst MW. Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2013 May 27;8578.

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

Publication Date

May 27, 2013

Volume

8578