Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor


Journal Article

Many studies have found that hypoxia, particularly cycling hypoxia (CH), can lead to enhanced tumor metastasis and resistance to radiation and chemotherapy. It was also reported that tumor total hemoglobin content (THb), which is directly related to tumor angiogenesis, can have significant impact on tumor's response to radiation and neoadjuvant chemotherapy. There is a growing demand for technologies to measure tumor hypoxia and angiogenesis temporally in vivo. In this paper, a side-firing fiber optic sensor based on a multi-wavelength frequency-domain near infrared spectroscopy (FD-NIRS) instrument was used to quantify tumor oxygenation and hemoglobin concentrations in nude rats bearing human FaDu head and neck (H & N) tumors during normoxia and forced hyperoxia and cyclic hypoxia. Significant increase (with carbogen gas inhalation) or decrease (with reduced O2 supply) in tumor oxygenation was observed. The studies demonstrated the feasibility of the technology for longitudinal monitoring of H and N tumor's response to therapy. © 2013 Copyright SPIE.

Full Text

Duke Authors

Cited Authors

  • Yu, B; Shah, A; Wang, B; Rajaram, N; Wang, Q; Ramanujam, N; Palmer, GM; Dewhirst, MW

Published Date

  • May 27, 2013

Published In

Volume / Issue

  • 8578 /

International Standard Serial Number (ISSN)

  • 1605-7422

Digital Object Identifier (DOI)

  • 10.1117/12.2002837

Citation Source

  • Scopus