An ethanolamine-phosphate modified glycolipid in Clostridium acetobutylicum that responds to membrane stress.

Published

Journal Article

Two phosphorus-containing glycolipids have previously been observed in Clostridium acetobutylicum. We had shown that the concentration of one of them increases in response to increased unsaturation of the membrane lipid hydrocarbon chains, suggesting a potential role in the regulation of lipid polymorphism in this organism. Mass spectrometry shows that these glycolipids are ethanolamine phosphate (Etn-P)-containing derivatives of a mono- and di-glycosyldiradylglycerol. The content of both diglycosyldiradylglycerol and the Etn-P-monoglycosyldiradylglycerol, which increases upon increased unsaturation of the membrane, also increases upon addition of octanol to the medium. Thus, it appears that the Etn-P-monoglycosyldiradylglycerol along with the diglycosyldiradylglycerol may serve to stabilize the membrane bilayer during membrane stress caused by the presence of the solvents produced during fermentation.

Full Text

Duke Authors

Cited Authors

  • Tian, B; Guan, Z; Goldfine, H

Published Date

  • June 2013

Published In

Volume / Issue

  • 1831 / 6

Start / End Page

  • 1185 - 1190

PubMed ID

  • 23542061

Pubmed Central ID

  • 23542061

Electronic International Standard Serial Number (EISSN)

  • 1878-2434

International Standard Serial Number (ISSN)

  • 0006-3002

Digital Object Identifier (DOI)

  • 10.1016/j.bbalip.2013.03.005

Language

  • eng