Insertion of arynes into N-halo bonds: a direct approach to o-haloaminoarenes.

Journal Article (Journal Article)

A new approach to access o-haloaminoarenes has been achieved by insertion of arynes into a nitrogen-halide bond (N-X). This transition-metal-free transformation displays a broad substrate scope of arynes, good compatibility with functional groups, and high regioselectivity. Representative transformations of the o-haloaminoarenes are described to highlight their utility for rapid access to diversely functionalized aminoarene derivatives.

Full Text

Duke Authors

Cited Authors

  • Hendrick, CE; McDonald, SL; Wang, Q

Published Date

  • July 2013

Published In

Volume / Issue

  • 15 / 13

Start / End Page

  • 3444 - 3447

PubMed ID

  • 23796022

Pubmed Central ID

  • PMC4779594

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol401518c


  • eng