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Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease.

Publication ,  Journal Article
Wansleeben, C; Barkauskas, CE; Rock, JR; Hogan, BLM
Published in: Wiley Interdiscip Rev Dev Biol
2013

The lung has vital functions in gas exchange and immune defense. To fulfill these functions the cellular composition and complex three-dimensional organization of the organ must be maintained for a lifetime. Cell turnover in the adult lung is normally low. However, in response to cellular injury by agents such as infection, toxic compounds, and irradiation there is rapid proliferation and differentiation of endogenous stem and progenitor cells to repair and regenerate the damaged tissue. In the mouse, different populations of epithelial progenitor cells have been identified in different regions of the respiratory system: basal cells in the proximal tracheobronchial region and submucosal glands, and secretory cells in the conducting airways and bronchioalveolar duct junction. The identification of the long-term stem cells in the alveolar region is still under debate, and little is known about resident stem and progenitor cells for the many mesodermal populations. Within this framework information is provided about the origin of lung progenitor cells during development, the microenvironment in which they reside, the experimental injury and repair systems used to promote their regenerative response, and some of the mechanisms regulating their behavior. WIREs Dev Biol 2013, 2:131-148. doi: 10.1002/wdev.58 For further resources related to this article, please visit the WIREs website.

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Published In

Wiley Interdiscip Rev Dev Biol

DOI

EISSN

1759-7692

Publication Date

2013

Volume

2

Issue

1

Start / End Page

131 / 148

Location

United States

Related Subject Headings

  • Wound Healing
  • Stem Cells
  • Regeneration
  • Mice
  • Lung
  • Humans
  • Homeostasis
  • Cell Differentiation
  • Animals
  • 3108 Plant biology
 

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Wansleeben, C., Barkauskas, C. E., Rock, J. R., & Hogan, B. L. M. (2013). Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease. Wiley Interdiscip Rev Dev Biol, 2(1), 131–148. https://doi.org/10.1002/wdev.58
Wansleeben, Carolien, Christina E. Barkauskas, Jason R. Rock, and Brigid L. M. Hogan. “Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease.Wiley Interdiscip Rev Dev Biol 2, no. 1 (2013): 131–48. https://doi.org/10.1002/wdev.58.
Wansleeben C, Barkauskas CE, Rock JR, Hogan BLM. Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease. Wiley Interdiscip Rev Dev Biol. 2013;2(1):131–48.
Wansleeben, Carolien, et al. “Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease.Wiley Interdiscip Rev Dev Biol, vol. 2, no. 1, 2013, pp. 131–48. Pubmed, doi:10.1002/wdev.58.
Wansleeben C, Barkauskas CE, Rock JR, Hogan BLM. Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease. Wiley Interdiscip Rev Dev Biol. 2013;2(1):131–148.
Journal cover image

Published In

Wiley Interdiscip Rev Dev Biol

DOI

EISSN

1759-7692

Publication Date

2013

Volume

2

Issue

1

Start / End Page

131 / 148

Location

United States

Related Subject Headings

  • Wound Healing
  • Stem Cells
  • Regeneration
  • Mice
  • Lung
  • Humans
  • Homeostasis
  • Cell Differentiation
  • Animals
  • 3108 Plant biology