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Ultrasonic characterization of the nonlinear properties of canine livers by measuring shear wave speed and axial strain with increasing portal venous pressure.

Publication ,  Journal Article
Rotemberg, V; Byram, B; Palmeri, M; Wang, M; Nightingale, K
Published in: Journal of biomechanics
July 2013

Elevated hepatic venous pressure is the primary source of complications in advancing liver disease. Ultrasound imaging is ideal for potential noninvasive hepatic pressure measurements as it is widely used for liver imaging. Specifically, ultrasound based stiffness measures may be useful for clinically monitoring pressure, but the mechanism by which liver stiffness increases with hepatic pressure has not been well characterized. This study is designed to elucidate the nonlinear properties of the liver during pressurization by measuring both hepatic shear wave speed (SWS) and strain with increasing pressure. Tissue deformation during hepatic pressurization was tracked in 8 canine livers using successively acquired 3-D B-mode volumes and compared with concurrently measured SWS. When portal venous pressure was increased from clinically normal (0-5mmHg) to pressures representing highly diseased states at 20mmHg, the liver was observed to expand with axial strain measures up to 10%. At the same time, SWS estimates were observed to increase from 1.5-2m/s at 0-5mmHg (baseline) to 3.25-3.5m/s at 20mmHg.

Duke Scholars

Published In

Journal of biomechanics

DOI

EISSN

1873-2380

ISSN

0021-9290

Publication Date

July 2013

Volume

46

Issue

11

Start / End Page

1875 / 1881

Related Subject Headings

  • Vascular Stiffness
  • Ultrasonography
  • Portal Vein
  • Portal Pressure
  • Nonlinear Dynamics
  • Models, Cardiovascular
  • Liver Circulation
  • Liver
  • Dogs
  • Biomedical Engineering
 

Citation

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ICMJE
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Rotemberg, V., Byram, B., Palmeri, M., Wang, M., & Nightingale, K. (2013). Ultrasonic characterization of the nonlinear properties of canine livers by measuring shear wave speed and axial strain with increasing portal venous pressure. Journal of Biomechanics, 46(11), 1875–1881. https://doi.org/10.1016/j.jbiomech.2013.04.027
Rotemberg, Veronica, Brett Byram, Mark Palmeri, Michael Wang, and Kathryn Nightingale. “Ultrasonic characterization of the nonlinear properties of canine livers by measuring shear wave speed and axial strain with increasing portal venous pressure.Journal of Biomechanics 46, no. 11 (July 2013): 1875–81. https://doi.org/10.1016/j.jbiomech.2013.04.027.
Rotemberg V, Byram B, Palmeri M, Wang M, Nightingale K. Ultrasonic characterization of the nonlinear properties of canine livers by measuring shear wave speed and axial strain with increasing portal venous pressure. Journal of biomechanics. 2013 Jul;46(11):1875–81.
Rotemberg, Veronica, et al. “Ultrasonic characterization of the nonlinear properties of canine livers by measuring shear wave speed and axial strain with increasing portal venous pressure.Journal of Biomechanics, vol. 46, no. 11, July 2013, pp. 1875–81. Epmc, doi:10.1016/j.jbiomech.2013.04.027.
Rotemberg V, Byram B, Palmeri M, Wang M, Nightingale K. Ultrasonic characterization of the nonlinear properties of canine livers by measuring shear wave speed and axial strain with increasing portal venous pressure. Journal of biomechanics. 2013 Jul;46(11):1875–1881.
Journal cover image

Published In

Journal of biomechanics

DOI

EISSN

1873-2380

ISSN

0021-9290

Publication Date

July 2013

Volume

46

Issue

11

Start / End Page

1875 / 1881

Related Subject Headings

  • Vascular Stiffness
  • Ultrasonography
  • Portal Vein
  • Portal Pressure
  • Nonlinear Dynamics
  • Models, Cardiovascular
  • Liver Circulation
  • Liver
  • Dogs
  • Biomedical Engineering