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Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group.

Publication ,  Journal Article
Husain, AN; Colby, T; Ordonez, N; Krausz, T; Attanoos, R; Beasley, MB; Borczuk, AC; Butnor, K; Cagle, PT; Chirieac, LR; Churg, A; Dacic, S ...
Published in: Arch Pathol Lab Med
May 2013

CONTEXT: Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. OBJECTIVE: To provide updated practical guidelines for the pathologic diagnosis of MM. DATA SOURCES: Pathologists involved in the International Mesothelioma Interest Group and others with an interest in the field contributed to this update. Reference material includes peer-reviewed publications and textbooks. CONCLUSIONS: There was consensus opinion regarding (1) distinction of benign from malignant mesothelial proliferations (both epithelioid and spindle cell lesions), (2) cytologic diagnosis of MM, (3) key histologic features of pleural and peritoneal MM, (4) use of histochemical and immunohistochemical stains in the diagnosis and differential diagnosis of MM, (5) differentiation of epithelioid MM from various carcinomas (lung, breast, ovarian, and colonic adenocarcinomas, and squamous cell and renal cell carcinomas), (6) diagnosis of sarcomatoid mesothelioma, (7) use of molecular markers in the diagnosis of MM, (8) electron microscopy in the diagnosis of MM, and (9) some caveats and pitfalls in the diagnosis of MM. Immunohistochemical panels are integral to the diagnosis of MM, but the exact makeup of panels used is dependent on the differential diagnosis and on the antibodies available in a given laboratory. Immunohistochemical panels should contain both positive and negative markers. It is recommended that immunohistochemical markers have either sensitivity or specificity greater than 80% for the lesions in question. Interpretation of positivity generally should take into account the localization of the stain (eg, nuclear versus cytoplasmic) and the percentage of cells staining (>10% is suggested for cytoplasmic membranous markers). These guidelines are meant to be a practical reference for the pathologist.

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Published In

Arch Pathol Lab Med

DOI

EISSN

1543-2165

Publication Date

May 2013

Volume

137

Issue

5

Start / End Page

647 / 667

Location

United States

Related Subject Headings

  • Pleural Neoplasms
  • Pathology
  • Mesothelioma, Malignant
  • Mesothelioma
  • Lung Neoplasms
  • Humans
  • Diagnosis, Differential
  • Adenocarcinoma
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Husain, A. N., Colby, T., Ordonez, N., Krausz, T., Attanoos, R., Beasley, M. B., … International Mesothelioma Interest Group, . (2013). Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med, 137(5), 647–667. https://doi.org/10.5858/arpa.2012-0214-OA
Husain, Aliya N., Thomas Colby, Nelson Ordonez, Thomas Krausz, Richard Attanoos, Mary Beth Beasley, Alain C. Borczuk, et al. “Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group.Arch Pathol Lab Med 137, no. 5 (May 2013): 647–67. https://doi.org/10.5858/arpa.2012-0214-OA.
Husain AN, Colby T, Ordonez N, Krausz T, Attanoos R, Beasley MB, et al. Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med. 2013 May;137(5):647–67.
Husain, Aliya N., et al. “Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group.Arch Pathol Lab Med, vol. 137, no. 5, May 2013, pp. 647–67. Pubmed, doi:10.5858/arpa.2012-0214-OA.
Husain AN, Colby T, Ordonez N, Krausz T, Attanoos R, Beasley MB, Borczuk AC, Butnor K, Cagle PT, Chirieac LR, Churg A, Dacic S, Fraire A, Galateau-Salle F, Gibbs A, Gown A, Hammar S, Litzky L, Marchevsky AM, Nicholson AG, Roggli V, Travis WD, Wick M, International Mesothelioma Interest Group. Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med. 2013 May;137(5):647–667.

Published In

Arch Pathol Lab Med

DOI

EISSN

1543-2165

Publication Date

May 2013

Volume

137

Issue

5

Start / End Page

647 / 667

Location

United States

Related Subject Headings

  • Pleural Neoplasms
  • Pathology
  • Mesothelioma, Malignant
  • Mesothelioma
  • Lung Neoplasms
  • Humans
  • Diagnosis, Differential
  • Adenocarcinoma
  • 3202 Clinical sciences
  • 1103 Clinical Sciences