Concepts of blood transfusion in adults.

Other Article (Journal Article;Review)

Recent progress has been made in the identification and implementation of best transfusion practices on the basis of evidence-based clinical trials, published clinical practice guidelines, and process improvements for blood use and clinical patient outcomes. However, substantial variability persists in transfusion outcomes for patients in some clinical settings--eg, patients undergoing cardiothoracic surgery. This variability could be the result of insufficient understanding of published guidelines; different recommendations of medical societies, including the specification of a haemoglobin concentration threshold to use as a transfusion trigger; the value of haemoglobin as a surrogate indicator for transfusion benefit, even though only changes in concentration and not absolute red cell mass of haemoglobin can be identified; and disagreement about the validity of the level 1 evidence for clinical practice guidelines. Nevertheless, institutional experience and national databases suggest that a restrictive blood transfusion approach is being increasingly implemented as best practice.

Full Text

Duke Authors

Cited Authors

  • Goodnough, LT; Levy, JH; Murphy, MF

Published Date

  • May 25, 2013

Published In

Volume / Issue

  • 381 / 9880

Start / End Page

  • 1845 - 1854

PubMed ID

  • 23706801

Electronic International Standard Serial Number (EISSN)

  • 1474-547X

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(13)60650-9


  • eng

Conference Location

  • England