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Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging.

Publication ,  Journal Article
Kaushik, SS; Freeman, MS; Cleveland, ZI; Davies, J; Stiles, J; Virgincar, RS; Robertson, SH; He, M; Kelly, KT; Foster, WM; McAdams, HP; Driehuys, B
Published in: J Appl Physiol (1985)
September 2013

Although some central aspects of pulmonary function (ventilation and perfusion) are known to be heterogeneous, the distribution of diffusive gas exchange remains poorly characterized. A solution is offered by hyperpolarized 129Xe magnetic resonance (MR) imaging, because this gas can be separately detected in the lung's air spaces and dissolved in its tissues. Early dissolved-phase 129Xe images exhibited intensity gradients that favored the dependent lung. To quantitatively corroborate this finding, we developed an interleaved, three-dimensional radial sequence to image the gaseous and dissolved 129Xe distributions in the same breath. These images were normalized and divided to calculate "129Xe gas-transfer" maps. We hypothesized that, for healthy volunteers, 129Xe gas-transfer maps would retain the previously observed posture-dependent gradients. This was tested in nine subjects: when the subjects were supine, 129Xe gas transfer exhibited a posterior-anterior gradient of -2.00 ± 0.74%/cm; when the subjects were prone, the gradient reversed to 1.94 ± 1.14%/cm (P < 0.001). The 129Xe gas-transfer maps also exhibited significant heterogeneity, as measured by the coefficient of variation, that correlated with subject total lung capacity (r = 0.77, P = 0.015). Gas-transfer intensity varied nonmonotonically with slice position and increased in slices proximal to the main pulmonary arteries. Despite substantial heterogeneity, the mean gas transfer for all subjects was 1.00 ± 0.01 while supine and 1.01 ± 0.01 while prone (P = 0.25), indicating good "matching" between gas- and dissolved-phase distributions. This study demonstrates that single-breath gas- and dissolved-phase 129Xe MR imaging yields 129Xe gas-transfer maps that are sensitive to altered gas exchange caused by differences in lung inflation and posture.

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Published In

J Appl Physiol (1985)

DOI

EISSN

1522-1601

Publication Date

September 2013

Volume

115

Issue

6

Start / End Page

850 / 860

Location

United States

Related Subject Headings

  • Young Adult
  • Xenon Isotopes
  • Supine Position
  • Pulmonary Gas Exchange
  • Prone Position
  • Physiology
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Lung
 

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Kaushik, S. S., Freeman, M. S., Cleveland, Z. I., Davies, J., Stiles, J., Virgincar, R. S., … Driehuys, B. (2013). Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging. J Appl Physiol (1985), 115(6), 850–860. https://doi.org/10.1152/japplphysiol.00092.2013
Kaushik, S Sivaram, Matthew S. Freeman, Zackary I. Cleveland, John Davies, Jane Stiles, Rohan S. Virgincar, Scott H. Robertson, et al. “Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging.J Appl Physiol (1985) 115, no. 6 (September 2013): 850–60. https://doi.org/10.1152/japplphysiol.00092.2013.
Kaushik SS, Freeman MS, Cleveland ZI, Davies J, Stiles J, Virgincar RS, et al. Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging. J Appl Physiol (1985). 2013 Sep;115(6):850–60.
Kaushik, S. Sivaram, et al. “Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging.J Appl Physiol (1985), vol. 115, no. 6, Sept. 2013, pp. 850–60. Pubmed, doi:10.1152/japplphysiol.00092.2013.
Kaushik SS, Freeman MS, Cleveland ZI, Davies J, Stiles J, Virgincar RS, Robertson SH, He M, Kelly KT, Foster WM, McAdams HP, Driehuys B. Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging. J Appl Physiol (1985). 2013 Sep;115(6):850–860.

Published In

J Appl Physiol (1985)

DOI

EISSN

1522-1601

Publication Date

September 2013

Volume

115

Issue

6

Start / End Page

850 / 860

Location

United States

Related Subject Headings

  • Young Adult
  • Xenon Isotopes
  • Supine Position
  • Pulmonary Gas Exchange
  • Prone Position
  • Physiology
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Lung