Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.
Five novel tigliane-type diterpenes, stelleracins A-E (3-7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3-5 showed potent anti-HIV activity (EC90 0.00056-0.0068 μM) and relatively low or no cytotoxicity (IC50 4.4-17.2 μM). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates.
Asada, Y; Sukemori, A; Watanabe, T; Malla, KJ; Yoshikawa, T; Li, W; Kuang, X; Koike, K; Chen, C-H; Akiyama, T; Qian, K; Nakagawa-Goto, K; Morris-Natschke, SL; Lu, Y; Lee, K-H
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