Mechanical regulation of chondrogenesis.

JOURNAL ARTICLE

Mechanical factors play a crucial role in the development of articular cartilage in vivo. In this regard, tissue engineers have sought to leverage native mechanotransduction pathways to enhance in vitro stem cell-based cartilage repair strategies. However, a thorough understanding of how individual mechanical factors influence stem cell fate is needed to predictably and effectively utilize this strategy of mechanically-induced chondrogenesis. This article summarizes some of the latest findings on mechanically stimulated chondrogenesis, highlighting several new areas of interest, such as the effects of mechanical stimulation on matrix maintenance and terminal differentiation, as well as the use of multifactorial bioreactors. Additionally, the roles of individual biophysical factors, such as hydrostatic or osmotic pressure, are examined in light of their potential to induce mesenchymal stem cell chondrogenesis. An improved understanding of biomechanically-driven tissue development and maturation of stem cell-based cartilage replacements will hopefully lead to the development of cell-based therapies for cartilage degeneration and disease.

Full Text

Duke Authors

Cited Authors

  • O'Conor, CJ; Case, N; Guilak, F

Published Date

  • July 2013

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 61 -

PubMed ID

  • 23809493

Electronic International Standard Serial Number (EISSN)

  • 1757-6512

Digital Object Identifier (DOI)

  • 10.1186/scrt211

Language

  • ENG

Citation Source

  • PubMed