Does change in acetylcholine receptor antibody level correlate with clinical change in myasthenia gravis?

Journal Article (Clinical Trial;Journal Article)

INTRODUCTION: The objective of this study is to determine if change in acetylcholine receptor antibody (AChR-ab) levels reflects change in clinical severity in patients with myasthenia gravis (MG). METHODS: We reviewed results from a prospective trial in MG and from all 85 patients in an MG Clinic who had AChR-ab determinations performed at least twice by the same commercial laboratory. RESULTS: Change in AChR-ab levels correlated only weakly with change in clinical severity. AChR-ab levels fell in 92% of patients who improved and in 63% who did not. A fall in AChR-ab level had a positive predictive value for clinical improvement of 83% and a negative predictive value of only 59%. CONCLUSIONS: AChR-ab levels fell in almost all patients who improved, but also in most patients who did not. Thus, we do not recommend commercially available AChR-ab levels as a biomarker of improvement in MG. However, antibody levels might be useful as a marker for inadequate immunotherapy.

Full Text

Duke Authors

Cited Authors

  • Sanders, DB; Burns, TM; Cutter, GR; Massey, JM; Juel, VC; Hobson-Webb, L; Muscle Study Group,

Published Date

  • April 2014

Published In

Volume / Issue

  • 49 / 4

Start / End Page

  • 483 - 486

PubMed ID

  • 23835683

Electronic International Standard Serial Number (EISSN)

  • 1097-4598

Digital Object Identifier (DOI)

  • 10.1002/mus.23944


  • eng

Conference Location

  • United States