Skip to main content
Journal cover image

Biomarkers in atrial fibrillation: a clinical review.

Publication ,  Journal Article
Hijazi, Z; Oldgren, J; Siegbahn, A; Granger, CB; Wallentin, L
Published in: Eur Heart J
May 2013

Assessment of atrial fibrillation (AF)-associated stroke risk is at present mainly based on clinical risk scores such as CHADS2 and CHA2DS2-VASc, although these scores provide only modest discrimination of risk for individual patients. Biomarkers derived from the blood may help refine risk assessment in AF for stroke outcomes and for mortality. Recent studies of biomarkers in AF have shown that they can substantially improve risk stratification. Cardiac biomarkers, such as troponin and natriuretic peptides, significantly improve risk stratification in addition to current clinical risk stratification models. Similar findings have recently been described for markers of renal function, coagulation, and inflammation in AF populations based on large randomized prospective clinical trials or large community-based cohorts. These new findings may enable development of novel tools to improve clinical risk assessment in AF. Biomarkers in AF may also improve the understanding of the pathophysiology of AF further as well as potentially elucidate novel treatment targets. This review will highlight novel associations of biomarkers and outcomes in AF as well as recent progress in the use of biomarkers for risk stratification.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Eur Heart J

DOI

EISSN

1522-9645

Publication Date

May 2013

Volume

34

Issue

20

Start / End Page

1475 / 1480

Location

England

Related Subject Headings

  • Troponin I
  • Risk Assessment
  • Natriuretic Peptide, Brain
  • Interleukin-6
  • Humans
  • Glomerular Filtration Rate
  • Forecasting
  • Fibrin Fibrinogen Degradation Products
  • Echocardiography
  • Cystatin C
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hijazi, Z., Oldgren, J., Siegbahn, A., Granger, C. B., & Wallentin, L. (2013). Biomarkers in atrial fibrillation: a clinical review. Eur Heart J, 34(20), 1475–1480. https://doi.org/10.1093/eurheartj/eht024
Hijazi, Ziad, Jonas Oldgren, Agneta Siegbahn, Christopher B. Granger, and Lars Wallentin. “Biomarkers in atrial fibrillation: a clinical review.Eur Heart J 34, no. 20 (May 2013): 1475–80. https://doi.org/10.1093/eurheartj/eht024.
Hijazi Z, Oldgren J, Siegbahn A, Granger CB, Wallentin L. Biomarkers in atrial fibrillation: a clinical review. Eur Heart J. 2013 May;34(20):1475–80.
Hijazi, Ziad, et al. “Biomarkers in atrial fibrillation: a clinical review.Eur Heart J, vol. 34, no. 20, May 2013, pp. 1475–80. Pubmed, doi:10.1093/eurheartj/eht024.
Hijazi Z, Oldgren J, Siegbahn A, Granger CB, Wallentin L. Biomarkers in atrial fibrillation: a clinical review. Eur Heart J. 2013 May;34(20):1475–1480.
Journal cover image

Published In

Eur Heart J

DOI

EISSN

1522-9645

Publication Date

May 2013

Volume

34

Issue

20

Start / End Page

1475 / 1480

Location

England

Related Subject Headings

  • Troponin I
  • Risk Assessment
  • Natriuretic Peptide, Brain
  • Interleukin-6
  • Humans
  • Glomerular Filtration Rate
  • Forecasting
  • Fibrin Fibrinogen Degradation Products
  • Echocardiography
  • Cystatin C