Role of ABL family kinases in cancer: from leukaemia to solid tumours.

Journal Article (Review)

The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse extracellular signals to protein networks that control proliferation, survival, migration and invasion. ABL1 was first identified as an oncogene required for the development of leukaemias initiated by retroviruses or chromosome translocations. The demonstration that small-molecule ABL kinase inhibitors could effectively treat chronic myeloid leukaemia opened the door to the era of targeted cancer therapies. Recent reports have uncovered roles for ABL kinases in solid tumours. Enhanced ABL expression and activation in some solid tumours, together with altered cell polarity, invasion or growth induced by activated ABL kinases, suggest that drugs targeting these kinases may be useful for treating selected solid tumours.

Full Text

Duke Authors

Cited Authors

  • Greuber, EK; Smith-Pearson, P; Wang, J; Pendergast, AM

Published Date

  • August 2013

Published In

Volume / Issue

  • 13 / 8

Start / End Page

  • 559 - 571

PubMed ID

  • 23842646

Electronic International Standard Serial Number (EISSN)

  • 1474-1768

Digital Object Identifier (DOI)

  • 10.1038/nrc3563

Language

  • eng

Conference Location

  • England