Thymic rejuvenation and aging.

Published

Journal Article (Review)

The thymus is a vital organ for homeostatic maintenance of the peripheral immune system. It is within this mediastinal tissue that T cells develop and are extensively educated and exported to the periphery for establishment of a functional and effective immune system. A striking paradoxical feature of this critical lymphoid tissue is that it undergoes profound age-associated involution. Thymic decline is of minimal consequence to healthy individuals, but the reduced efficacy of the immune system with age has direct etiological linkages with an increase in diseases including opportunistic infections, autoimmunity, and incidence/burden of cancer. Furthermore the inability of adults to restore immune function following insult induced by chemotherapy, ionizing radiation exposure or therapy, and infections (e.g. HIV-1) leads to increased morbidity and often mortality in the elderly. For these reasons, it is important that investigators strive to translate their understanding of mechanisms that drive thymic involution, and develop safe and effective strategies to rejuvenate the thymus in settings of clinical need. In this review, we present a discussion of the current status of thymic rejuvenation efforts associated with: sex steroid ablation, cytokines, growth factors, and hormones.

Full Text

Duke Authors

Cited Authors

  • Ventevogel, MS; Sempowski, GD

Published Date

  • August 2013

Published In

Volume / Issue

  • 25 / 4

Start / End Page

  • 516 - 522

PubMed ID

  • 23831111

Pubmed Central ID

  • 23831111

Electronic International Standard Serial Number (EISSN)

  • 1879-0372

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2013.06.002

Language

  • eng

Conference Location

  • England