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Left bundle-branch block: the relationship between electrocardiogram electrical activation and echocardiography mechanical contraction.

Publication ,  Journal Article
Risum, N; Strauss, D; Sogaard, P; Loring, Z; Hansen, TF; Bruun, NE; Wagner, G; Kisslo, J
Published in: Am Heart J
August 2013

BACKGROUND: The relationship between myocardial electrical activation by electrocardiogram (ECG) and mechanical contraction by echocardiography in left bundle-branch block (LBBB) has never been clearly demonstrated. New strict criteria for LBBB based on a fundamental understanding of physiology have recently been independently published for both ECG and echocardiography. The relationship between the 2 modalities and the relation to cardiac resynchronization therapy (CRT) response was investigated. METHODS: Sixty-six patients with LBBB by conventional criteria had a standard 12-lead ECG and 2-dimensional strain echocardiography performed before CRT implantation. Criteria for LBBB by echocardiography included early termination of contraction in one wall and prestretch and late contraction in opposing wall(s). New strict criteria by ECG included QRS duration ≥140 ms (men) or 130 ms (women), QS or rS in leads V1 and V2, and mid-QRS notching or slurring in ≥2 of leads V1, V2, V5, V6, I, and aVL. Response was defined as >15% decrease in left ventricular end-systolic volume after 6 months. RESULTS: In 64 of 66 patients, ECG analysis was possible. Echo and ECG readings for LBBB presence were concordant in 54 (84%) of 64. Thirty-seven (82%) of 45 patients with LBBB by strict ECG criteria responded to CRT, whereas only 4 (21%) of the 19 patients without LBBB responded (sensitivity 90% and specificity 65%). Thirty-six (95%) of 38 patients with concordance for the presence of LBBB responded to CRT. In patients with concordance for the absence of LBBB, 15 (94%) of 16 did not respond. CONCLUSION: For the first time, a close relation has been demonstrated between electrical activation by ECG and mechanical contraction by echocardiography. These findings may help identify CRT candidates.

Duke Scholars

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

August 2013

Volume

166

Issue

2

Start / End Page

340 / 348

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
  • Electrophysiological Phenomena
  • Electrocardiography
  • Echocardiography
  • Cardiovascular System & Hematology
  • Cardiac Resynchronization Therapy
 

Citation

APA
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ICMJE
MLA
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Risum, N., Strauss, D., Sogaard, P., Loring, Z., Hansen, T. F., Bruun, N. E., … Kisslo, J. (2013). Left bundle-branch block: the relationship between electrocardiogram electrical activation and echocardiography mechanical contraction. Am Heart J, 166(2), 340–348. https://doi.org/10.1016/j.ahj.2013.04.005
Risum, Niels, David Strauss, Peter Sogaard, Zak Loring, Thomas Fritz Hansen, Niels Eske Bruun, Galen Wagner, and Joseph Kisslo. “Left bundle-branch block: the relationship between electrocardiogram electrical activation and echocardiography mechanical contraction.Am Heart J 166, no. 2 (August 2013): 340–48. https://doi.org/10.1016/j.ahj.2013.04.005.
Risum N, Strauss D, Sogaard P, Loring Z, Hansen TF, Bruun NE, et al. Left bundle-branch block: the relationship between electrocardiogram electrical activation and echocardiography mechanical contraction. Am Heart J. 2013 Aug;166(2):340–8.
Risum, Niels, et al. “Left bundle-branch block: the relationship between electrocardiogram electrical activation and echocardiography mechanical contraction.Am Heart J, vol. 166, no. 2, Aug. 2013, pp. 340–48. Pubmed, doi:10.1016/j.ahj.2013.04.005.
Risum N, Strauss D, Sogaard P, Loring Z, Hansen TF, Bruun NE, Wagner G, Kisslo J. Left bundle-branch block: the relationship between electrocardiogram electrical activation and echocardiography mechanical contraction. Am Heart J. 2013 Aug;166(2):340–348.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

August 2013

Volume

166

Issue

2

Start / End Page

340 / 348

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
  • Electrophysiological Phenomena
  • Electrocardiography
  • Echocardiography
  • Cardiovascular System & Hematology
  • Cardiac Resynchronization Therapy