Pump-Probe Microscopic Imaging of Jurassic-Aged Eumelanin.

Journal Article (Journal Article)

Melanins are biological pigments found throughout the animal kingdom that have many diverse functions. Pump-probe imaging can differentiate the two kinds of melanins found in human skin, eumelanin and pheomelanin, the distributions of which are relevant to the diagnosis of melanoma. The long-term stability of the melanin pump-probe signal is central to using this technology to analyze melanin distributions in archived tissue samples to improve diagnostic procedures. This report shows that most of the pump-probe signal from eumelanin derived from a Jurassic cephalopod is essentially identical to that of eumelanin extracted from its modern counterpart, Sepia officinalis . However, additional classes of eumelanin signals found in the fossil reveal that the pump-probe signature is sensitive to iron content, which could be a valuable tool for pathologists who cannot otherwise know the microscopic distributions of iron in melanins.

Full Text

Duke Authors

Cited Authors

  • Simpson, MJ; Glass, KE; Wilson, JW; Wilby, PR; Simon, JD; Warren, WS

Published Date

  • June 2013

Published In

Volume / Issue

  • 4 / 11

Start / End Page

  • 1924 - 1927

PubMed ID

  • 23847720

Pubmed Central ID

  • PMC3704187

Electronic International Standard Serial Number (EISSN)

  • 1948-7185

International Standard Serial Number (ISSN)

  • 1948-7185

Digital Object Identifier (DOI)

  • 10.1021/jz4008036


  • eng