More and more consumers are using the Internet to find answers to questions about healthcare. Unfortunately, information at health Web sites may be incorrect, biased, and outdated. The purpose of our project was to identify Web sites on sepsis that could be used for patient and family education. We evaluated 30 sites on the basis of the Health on the Net criteria for medical and health Web sites, key content areas that patients and families should know in relation to sepsis, and readability. This article shares the process we used to evaluate the Web sites and identify the top sites for patient education.