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Are there negative responders to exercise training among heart failure patients?

Publication ,  Journal Article
Leifer, ES; Brawner, CA; Fleg, JL; Kraus, WE; Whellan, DJ; Piña, IL; Keteyian, SJ
Published in: Med Sci Sports Exerc
February 2014

PURPOSE: Aerobic exercise training has been used in patients with stable heart failure (HF) to reduce the risk of clinical events. However, due to patient heterogeneity, some patients may experience a decrease in functional capacity due to such training. The purpose of this study was to estimate the proportion of HF patients participating in a training program who had negative responses to such therapy and to compare them with a concurrent control group. METHODS: Baseline and 3-month peak V˙O2 measurements were obtained on 1870 HF subjects who were randomized to receive either an exercise training program or a control program of usual care without exercise training. The exercise program consisted of supervised walking or stationary cycling 3 d·wk(-1) for 12 wk as well as a 2-d·wk(-1) home exercise program after completing 18 supervised sessions. A negative response was defined as a baseline-to-3-month decrease in peak V˙O2 of at least 5 mL·kg(-1) min(-1), which was two times the SD of the control group's change in peak V˙O2. RESULTS: The mean ± SD change in peak V˙O2 in the exercise group and control group was 0.8 ± 2.5 mL·kg(-1)min(-1) and 0.2 ± 2.5 mL·kg(-1)min(-1), respectively (P < 0.001). The percentage of negative responders in the exercise and control groups was 0.9% and 2.3% (P = 0.02). CONCLUSIONS: The low negative response rate in the exercise group combined with the slightly higher rate in the control group and equal variability in the exercise and control groups suggests that few if any subjects had training-related negative peak V˙O2 responses. These findings support current exercise recommendations for HF patients.

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Published In

Med Sci Sports Exerc

DOI

EISSN

1530-0315

Publication Date

February 2014

Volume

46

Issue

2

Start / End Page

219 / 224

Location

United States

Related Subject Headings

  • Walking
  • Sport Sciences
  • Oxygen Consumption
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Female
  • Exercise Therapy
  • Bicycling
 

Citation

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Leifer, E. S., Brawner, C. A., Fleg, J. L., Kraus, W. E., Whellan, D. J., Piña, I. L., & Keteyian, S. J. (2014). Are there negative responders to exercise training among heart failure patients? Med Sci Sports Exerc, 46(2), 219–224. https://doi.org/10.1249/MSS.0b013e3182a44164
Leifer, Eric S., Clinton A. Brawner, Jerome L. Fleg, William E. Kraus, David J. Whellan, Ileana L. Piña, and Steven J. Keteyian. “Are there negative responders to exercise training among heart failure patients?Med Sci Sports Exerc 46, no. 2 (February 2014): 219–24. https://doi.org/10.1249/MSS.0b013e3182a44164.
Leifer ES, Brawner CA, Fleg JL, Kraus WE, Whellan DJ, Piña IL, et al. Are there negative responders to exercise training among heart failure patients? Med Sci Sports Exerc. 2014 Feb;46(2):219–24.
Leifer, Eric S., et al. “Are there negative responders to exercise training among heart failure patients?Med Sci Sports Exerc, vol. 46, no. 2, Feb. 2014, pp. 219–24. Pubmed, doi:10.1249/MSS.0b013e3182a44164.
Leifer ES, Brawner CA, Fleg JL, Kraus WE, Whellan DJ, Piña IL, Keteyian SJ. Are there negative responders to exercise training among heart failure patients? Med Sci Sports Exerc. 2014 Feb;46(2):219–224.

Published In

Med Sci Sports Exerc

DOI

EISSN

1530-0315

Publication Date

February 2014

Volume

46

Issue

2

Start / End Page

219 / 224

Location

United States

Related Subject Headings

  • Walking
  • Sport Sciences
  • Oxygen Consumption
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Female
  • Exercise Therapy
  • Bicycling