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Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants.

Publication ,  Journal Article
Vidal, AC; Murtha, AP; Murphy, SK; Fortner, K; Overcash, F; Henry, N; Schildkraut, JM; Forman, MR; Demark-Wahnefried, W; Kurtzberg, J; Hoyo, C ...
Published in: Int J Pediatr
2013

At birth, elevated IGF-I levels have been linked to birth weight extremes; high birth weight and low birth weight are risk factors for adult-onset chronic diseases including obesity, cardiovascular disease, and type 2 diabetes. We examined associations between plasma IGF-I levels and birth weight among infants born to African American and White obese and nonobese women. Prepregnancy weight and height were assessed among 251 pregnant women and anthropometric measurements of full term infants (≥37 weeks of gestation) were taken at birth. Circulating IGF-I was measured by ELISA in umbilical cord blood plasma. Linear regression models were utilized to examine associations between birth weight and high IGF-I, using the bottom two tertiles as referents. Compared with infants with lower IGF-I levels (≤3rd tertile), those with higher IGF-I levels (>3rd tertile) were 130 g heavier at birth, (β-coefficient = 230, se = 58.0, P = 0.0001), after adjusting for gender, race/ethnicity, gestational age, delivery route, maternal BMI and smoking. Stratified analyses suggested that these associations are more pronounced in infants born to African American women and women with BMI ≥30 kg/m(2); the cross product term for IGF-I and maternal BMI was statistically significant (P ≤ 0.0004). Our findings suggest that the association between IGF-I levels and birth weight depends more on maternal obesity than African American race/ethnicity.

Duke Scholars

Published In

Int J Pediatr

DOI

ISSN

1687-9740

Publication Date

2013

Volume

2013

Start / End Page

191472

Location

Egypt

Related Subject Headings

  • 3213 Paediatrics
 

Citation

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Vidal, A. C., Murtha, A. P., Murphy, S. K., Fortner, K., Overcash, F., Henry, N., … Hoyo, C. (2013). Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants. Int J Pediatr, 2013, 191472. https://doi.org/10.1155/2013/191472
Vidal, Adriana C., Amy P. Murtha, Susan K. Murphy, Kimberly Fortner, Francine Overcash, Nikki Henry, Joellen M. Schildkraut, et al. “Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants.Int J Pediatr 2013 (2013): 191472. https://doi.org/10.1155/2013/191472.
Vidal AC, Murtha AP, Murphy SK, Fortner K, Overcash F, Henry N, et al. Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants. Int J Pediatr. 2013;2013:191472.
Vidal, Adriana C., et al. “Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants.Int J Pediatr, vol. 2013, 2013, p. 191472. Pubmed, doi:10.1155/2013/191472.
Vidal AC, Murtha AP, Murphy SK, Fortner K, Overcash F, Henry N, Schildkraut JM, Forman MR, Demark-Wahnefried W, Kurtzberg J, Jirtle R, Hoyo C. Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants. Int J Pediatr. 2013;2013:191472.
Journal cover image

Published In

Int J Pediatr

DOI

ISSN

1687-9740

Publication Date

2013

Volume

2013

Start / End Page

191472

Location

Egypt

Related Subject Headings

  • 3213 Paediatrics