Mathematical modeling of kidney transport.

Published

Journal Article (Review)

In addition to metabolic waste and toxin excretion, the kidney also plays an indispensable role in regulating the balance of water, electrolytes, nitrogen, and acid-base. In this review, we describe representative mathematical models that have been developed to better understand kidney physiology and pathophysiology, including the regulation of glomerular filtration, the regulation of renal blood flow by means of the tubuloglomerular feedback mechanisms and of the myogenic mechanism, the urine concentrating mechanism, epithelial transport, and regulation of renal oxygen transport. We discuss the extent to which these modeling efforts have expanded our understanding of renal function in both health and disease.

Full Text

Duke Authors

Cited Authors

  • Layton, AT

Published Date

  • September 2013

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 557 - 573

PubMed ID

  • 23852667

Pubmed Central ID

  • 23852667

Electronic International Standard Serial Number (EISSN)

  • 1939-005X

International Standard Serial Number (ISSN)

  • 1939-5094

Digital Object Identifier (DOI)

  • 10.1002/wsbm.1232

Language

  • eng