TB: the Yin and Yang of lipid mediators.
Published
Journal Article (Review)
There is a growing appreciation of the diverse roles that lipid mediators play in modulating inflammatory responses during infection. In the case of tuberculosis, virulent mycobacteria induce host production of anti-inflammatory mediators, including lipoxins, which limit the host inflammatory response and lead to necrotic cell death of infected macrophages. Recent work using the zebrafish model suggests that, while excess anti-inflammatory lipoxins are host detrimental during mycobacterial infections, excess pro-inflammatory lipids also drive host susceptibility. The balance of these inflammatory states is influenced by common human genetic variation in Asia. Fuller understanding of the mechanisms of eicosanoid-mediated inflammatory imbalance during tuberculosis infection has important implications for the development of adjunctive therapies.
Full Text
Duke Authors
Cited Authors
- Tobin, DM; Ramakrishnan, L
Published Date
- August 2013
Published In
Volume / Issue
- 13 / 4
Start / End Page
- 641 - 645
PubMed ID
- 23849093
Pubmed Central ID
- 23849093
Electronic International Standard Serial Number (EISSN)
- 1471-4973
Digital Object Identifier (DOI)
- 10.1016/j.coph.2013.06.007
Language
- eng
Conference Location
- England