TB: the Yin and Yang of lipid mediators.

Journal Article (Journal Article;Review)

There is a growing appreciation of the diverse roles that lipid mediators play in modulating inflammatory responses during infection. In the case of tuberculosis, virulent mycobacteria induce host production of anti-inflammatory mediators, including lipoxins, which limit the host inflammatory response and lead to necrotic cell death of infected macrophages. Recent work using the zebrafish model suggests that, while excess anti-inflammatory lipoxins are host detrimental during mycobacterial infections, excess pro-inflammatory lipids also drive host susceptibility. The balance of these inflammatory states is influenced by common human genetic variation in Asia. Fuller understanding of the mechanisms of eicosanoid-mediated inflammatory imbalance during tuberculosis infection has important implications for the development of adjunctive therapies.

Full Text

Duke Authors

Cited Authors

  • Tobin, DM; Ramakrishnan, L

Published Date

  • August 2013

Published In

Volume / Issue

  • 13 / 4

Start / End Page

  • 641 - 645

PubMed ID

  • 23849093

Pubmed Central ID

  • PMC3756664

Electronic International Standard Serial Number (EISSN)

  • 1471-4973

Digital Object Identifier (DOI)

  • 10.1016/j.coph.2013.06.007


  • eng

Conference Location

  • England