Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.

Published

Journal Article

Three new members of the angucycline class of antibiotics, pseudonocardones A-C (1-3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1-3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.

Full Text

Duke Authors

Cited Authors

  • Carr, G; Derbyshire, ER; Caldera, E; Currie, CR; Clardy, J

Published Date

  • October 2012

Published In

Volume / Issue

  • 75 / 10

Start / End Page

  • 1806 - 1809

PubMed ID

  • 23025282

Pubmed Central ID

  • 23025282

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

International Standard Serial Number (ISSN)

  • 0163-3864

Digital Object Identifier (DOI)

  • 10.1021/np300380t

Language

  • eng