Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.

Journal Article (Journal Article)

Soluble guanylate cyclase (sGC) is activated by the known benzylindazole derivative YC-1 [1-benzyl-3-(5'-hydroxymethyl-2'-furyl)-indazole]. YC-1 also acts synergistically with CO, activating sGC to a level comparable to that achieved upon binding of nitric oxide, the endogenous activator of sGC. We here describe the synthesis of a YC-1 phosphonate analogue with improved aqueous solubility as well as its effects on sGC.

Full Text

Duke Authors

Cited Authors

  • Martin, NI; Derbyshire, ER; Marletta, MA

Published Date

  • September 2007

Published In

Volume / Issue

  • 17 / 17

Start / End Page

  • 4938 - 4941

PubMed ID

  • 17587571

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2007.06.039


  • eng