Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.
Publication
, Journal Article
Martin, NI; Derbyshire, ER; Marletta, MA
Published in: Bioorganic & medicinal chemistry letters
September 2007
Soluble guanylate cyclase (sGC) is activated by the known benzylindazole derivative YC-1 [1-benzyl-3-(5'-hydroxymethyl-2'-furyl)-indazole]. YC-1 also acts synergistically with CO, activating sGC to a level comparable to that achieved upon binding of nitric oxide, the endogenous activator of sGC. We here describe the synthesis of a YC-1 phosphonate analogue with improved aqueous solubility as well as its effects on sGC.
Duke Scholars
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
September 2007
Volume
17
Issue
17
Start / End Page
4938 / 4941
Related Subject Headings
- Temperature
- Soluble Guanylyl Cyclase
- Receptors, Cytoplasmic and Nuclear
- Phosphorylation
- Organophosphonates
- Nitric Oxide
- Models, Chemical
- Medicinal & Biomolecular Chemistry
- Kinetics
- Indazoles
Citation
APA
Chicago
ICMJE
MLA
NLM
Martin, N. I., Derbyshire, E. R., & Marletta, M. A. (2007). Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. Bioorganic & Medicinal Chemistry Letters, 17(17), 4938–4941. https://doi.org/10.1016/j.bmcl.2007.06.039
Martin, Nathaniel I., Emily R. Derbyshire, and Michael A. Marletta. “Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.” Bioorganic & Medicinal Chemistry Letters 17, no. 17 (September 2007): 4938–41. https://doi.org/10.1016/j.bmcl.2007.06.039.
Martin NI, Derbyshire ER, Marletta MA. Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. Bioorganic & medicinal chemistry letters. 2007 Sep;17(17):4938–41.
Martin, Nathaniel I., et al. “Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.” Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 17, Sept. 2007, pp. 4938–41. Epmc, doi:10.1016/j.bmcl.2007.06.039.
Martin NI, Derbyshire ER, Marletta MA. Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. Bioorganic & medicinal chemistry letters. 2007 Sep;17(17):4938–4941.
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
September 2007
Volume
17
Issue
17
Start / End Page
4938 / 4941
Related Subject Headings
- Temperature
- Soluble Guanylyl Cyclase
- Receptors, Cytoplasmic and Nuclear
- Phosphorylation
- Organophosphonates
- Nitric Oxide
- Models, Chemical
- Medicinal & Biomolecular Chemistry
- Kinetics
- Indazoles