Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.

Journal Article (Journal Article)

Soluble guanylate cyclase (sGC) is activated by the known benzylindazole derivative YC-1 [1-benzyl-3-(5'-hydroxymethyl-2'-furyl)-indazole]. YC-1 also acts synergistically with CO, activating sGC to a level comparable to that achieved upon binding of nitric oxide, the endogenous activator of sGC. We here describe the synthesis of a YC-1 phosphonate analogue with improved aqueous solubility as well as its effects on sGC.

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Duke Authors

Derbyshire, Emily R.

Cited Authors

Martin, NI; Derbyshire, ER; Marletta, MA

Published Date

September 2007

Published In

Bioorganic & Medicinal Chemistry Letters

Volume / Issue

17 / 17

Start / End Page

4938 - 4941

PubMed ID

17587571

Electronic International Standard Serial Number (EISSN)

1464-3405

International Standard Serial Number (ISSN)

0960-894X

Digital Object Identifier (DOI)

10.1016/j.bmcl.2007.06.039

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