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A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.

Publication ,  Journal Article
Pooley, KA; Bojesen, SE; Weischer, M; Nielsen, SF; Thompson, D; Amin Al Olama, A; Michailidou, K; Tyrer, JP; Benlloch, S; Brown, J; Audley, T ...
Published in: Hum Mol Genet
December 15, 2013

Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the "iCOGS" custom genotyping array. All ∼200 000 iCOGS variants were analysed with TL, and those displaying associations in healthy controls (n = 15 065) were further tested in breast cancer cases (n = 11 024). We found a novel TL association (Ptrend < 4 × 10(-10)) at 3p14.4 close to PXK and evidence (Ptrend < 7 × 10(-7)) for TL loci at 6p22.1 (ZNF311) and 20q11.2 (BCL2L1). We additionally confirmed (Ptrend < 5 × 10(-14)) the previously reported loci at 3q26.2 (TERC), 5p15.3 (TERT) and 10q24.3 (OBFC1) and found supportive evidence (Ptrend < 5 × 10(-4)) for the published loci at 2p16.2 (ACYP2), 4q32.2 (NAF1) and 20q13.3 (RTEL1). SNPs tagging these loci explain TL differences of up to 731 bp (corresponding to 18% of total TL in healthy individuals), however, they display little direct evidence for association with breast, ovarian or prostate cancer risks.

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Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

December 15, 2013

Volume

22

Issue

24

Start / End Page

5056 / 5064

Location

England

Related Subject Headings

  • Telomere Homeostasis
  • Telomere
  • Risk
  • Polymorphism, Single Nucleotide
  • Neoplasms
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity
  • Genetic Predisposition to Disease
 

Citation

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Pooley, K. A., Bojesen, S. E., Weischer, M., Nielsen, S. F., Thompson, D., Amin Al Olama, A., … Nordestgaard, B. G. (2013). A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet, 22(24), 5056–5064. https://doi.org/10.1093/hmg/ddt355
Pooley, Karen A., Stig E. Bojesen, Maren Weischer, Sune F. Nielsen, Deborah Thompson, Ali Amin Al Olama, Kyriaki Michailidou, et al. “A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.Hum Mol Genet 22, no. 24 (December 15, 2013): 5056–64. https://doi.org/10.1093/hmg/ddt355.
Pooley KA, Bojesen SE, Weischer M, Nielsen SF, Thompson D, Amin Al Olama A, et al. A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet. 2013 Dec 15;22(24):5056–64.
Pooley, Karen A., et al. “A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.Hum Mol Genet, vol. 22, no. 24, Dec. 2013, pp. 5056–64. Pubmed, doi:10.1093/hmg/ddt355.
Pooley KA, Bojesen SE, Weischer M, Nielsen SF, Thompson D, Amin Al Olama A, Michailidou K, Tyrer JP, Benlloch S, Brown J, Audley T, Luben R, Khaw K-T, Neal DE, Hamdy FC, Donovan JL, Kote-Jarai Z, Baynes C, Shah M, Bolla MK, Wang Q, Dennis J, Dicks E, Yang R, Rudolph A, Schildkraut J, Chang-Claude J, Burwinkel B, Chenevix-Trench G, Pharoah PDP, Berchuck A, Eeles RA, Easton DF, Dunning AM, Nordestgaard BG. A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet. 2013 Dec 15;22(24):5056–5064.
Journal cover image

Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

December 15, 2013

Volume

22

Issue

24

Start / End Page

5056 / 5064

Location

England

Related Subject Headings

  • Telomere Homeostasis
  • Telomere
  • Risk
  • Polymorphism, Single Nucleotide
  • Neoplasms
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity
  • Genetic Predisposition to Disease