Comparative mortality risks of antipsychotic medications in community-dwelling older adults.

Journal Article (Journal Article)

BACKGROUND: All antipsychotic medications carry warnings of increased mortality for older adults, but little is known about comparative mortality risks between individual agents. AIMS: To estimate the comparative mortality risks of commonly prescribed antipsychotic agents in older people living in the community. METHOD: A retrospective, claims-based cohort study was conducted of people over 65 years old living in the community who had been newly prescribed risperidone, olanzapine, quetiapine, haloperidol, aripiprazole or ziprasidone (n = 136 393). Propensity score-adjusted Cox proportional hazards models assessed the 180-day mortality risk of each antipsychotic compared with risperidone. RESULTS: Risperidone, olanzapine and haloperidol showed a dose-response relation in mortality risk. After controlling for propensity score and dose, mortality risk was found to be increased for haloperidol (hazard ratio (HR) = 1.18, 95% CI 1.06-1.33) and decreased for quetiapine (HR = 0.81, 95% CI 0.73-0.89) and olanzapine (HR = 0.82, 95% CI 0.74-0.90). CONCLUSIONS: Significant variation in mortality risk across commonly prescribed antipsychotics suggests that antipsychotic selection and dosing may affect survival of older people living in the community.

Full Text

Duke Authors

Cited Authors

  • Gerhard, T; Huybrechts, K; Olfson, M; Schneeweiss, S; Bobo, WV; Doraiswamy, PM; Devanand, DP; Lucas, JA; Huang, C; Malka, ES; Levin, R; Crystal, S

Published Date

  • July 2014

Published In

Volume / Issue

  • 205 / 1

Start / End Page

  • 44 - 51

PubMed ID

  • 23929443

Electronic International Standard Serial Number (EISSN)

  • 1472-1465

Digital Object Identifier (DOI)

  • 10.1192/bjp.bp.112.122499


  • eng

Conference Location

  • England