Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties.


Journal Article (Review)

Heart rate not only predicts outcome but may also be a therapeutic target in patients with chronic heart failure. Several classes of pharmacological agents can be used to modulate heart rate, including beta-blockers, ivabradine, digoxin, amiodarone, and verapamil. Choice of agent will depend on heart rhythm, co-morbidities, and disease phenotype. Beneficial and harmful interactions may also exist. The aim of this paper is to summarize the current body of knowledge regarding the relevance of heart rate as a prognostic factor (risk marker) and particularly as a therapeutic target (risk factor) in patients with chronic heart failure, with a special focus on ivabradine, a novel agent that is currently the only available purely bradycardic agent.

Full Text

Duke Authors

Cited Authors

  • Dobre, D; Borer, JS; Fox, K; Swedberg, K; Adams, KF; Cleland, JGF; Cohen-Solal, A; Gheorghiade, M; Gueyffier, F; O'Connor, CM; Fiuzat, M; Patak, A; Piña, IL; Rosano, G; Sabbah, HN; Tavazzi, L; Zannad, F

Published Date

  • January 2014

Published In

Volume / Issue

  • 16 / 1

Start / End Page

  • 76 - 85

PubMed ID

  • 23928650

Pubmed Central ID

  • 23928650

Electronic International Standard Serial Number (EISSN)

  • 1879-0844

Digital Object Identifier (DOI)

  • 10.1093/eurjhf/hft129


  • eng

Conference Location

  • England