Iron deprivation in cancer--potential therapeutic implications.

Published online

Journal Article (Review)

Iron is essential for normal cellular function. It participates in a wide variety of cellular processes, including cellular respiration, DNA synthesis, and macromolecule biosynthesis. Iron is required for cell growth and proliferation, and changes in intracellular iron availability can have significant effects on cell cycle regulation, cellular metabolism, and cell division. Perhaps not surprisingly then, neoplastic cells have been found to have higher iron requirements than normal, non-malignant cells. Iron depletion through chelation has been explored as a possible therapeutic intervention in a variety of cancers. Here, we will review iron homeostasis in non-malignant and malignant cells, the widespread effects of iron depletion on the cell, the various iron chelators that have been explored in the treatment of cancer, and the tumor types that have been most commonly studied in the context of iron chelation.

Full Text

Duke Authors

Cited Authors

  • Heath, JL; Weiss, JM; Lavau, CP; Wechsler, DS

Published Date

  • July 24, 2013

Published In

Volume / Issue

  • 5 / 8

Start / End Page

  • 2836 - 2859

PubMed ID

  • 23887041

Pubmed Central ID

  • 23887041

Electronic International Standard Serial Number (EISSN)

  • 2072-6643

Digital Object Identifier (DOI)

  • 10.3390/nu5082836

Language

  • eng

Conference Location

  • Switzerland