Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys.

Journal Article (Journal Article)

Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.

Full Text

Duke Authors

Cited Authors

  • Ho, C; Wu, S; Amos, JD; Colvin, L; Smith, SD; Wilks, AB; Demarco, CT; Brinkley, C; Denny, TN; Schmitz, JE; Rodrigo, AG; Permar, SR

Published Date

  • October 2013

Published In

Volume / Issue

  • 87 / 20

Start / End Page

  • 11292 - 11299

PubMed ID

  • 23926337

Pubmed Central ID

  • PMC3807282

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

Digital Object Identifier (DOI)

  • 10.1128/JVI.01643-13


  • eng

Conference Location

  • United States