The zebrafish as a model for complex tissue regeneration.

Published

Journal Article (Review)

For centuries, philosophers and scientists have been fascinated by the principles and implications of regeneration in lower vertebrate species. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. First, they are highly regenerative, able to regrow amputated fins, as well as a lesioned brain, retina, spinal cord, heart, and other tissues. Second, they are amenable to both forward and reverse genetic approaches, with a research toolset regularly updated by an expanding community of zebrafish researchers. Zebrafish studies have helped identify new mechanistic underpinnings of regeneration in multiple tissues and, in some cases, have served as a guide for contemplating regenerative strategies in mammals. Here, we review the recent history of zebrafish as a genetic model system for understanding how and why tissue regeneration occurs.

Full Text

Duke Authors

Cited Authors

  • Gemberling, M; Bailey, TJ; Hyde, DR; Poss, KD

Published Date

  • November 2013

Published In

Volume / Issue

  • 29 / 11

Start / End Page

  • 611 - 620

PubMed ID

  • 23927865

Pubmed Central ID

  • 23927865

International Standard Serial Number (ISSN)

  • 0168-9525

Digital Object Identifier (DOI)

  • 10.1016/j.tig.2013.07.003

Language

  • eng